Neuronal cell death occurs extensively during development and pathology, where it is
especially important because of the limited capacity of adult neurons to proliferate or be …

Ischemic stroke caused by intracranial vascular occlusion has become increasingly
prevalent with considerable mortality and disability, which gravely burdens the global …

The transition metal iron is essential for life, yet potentially toxic iron-catalyzed reactive
oxygen species (ROS) are unavoidable in an oxygen-rich environment. Iron and ROS are …

Ferroptosis is an intracellular iron-dependent form of cell death that is distinct from
apoptosis, necrosis, and autophagy. Extensive studies suggest that ferroptosis plays a …

Nonapoptotic forms of cell death may facilitate the selective elimination of some tumor cells
or be activated in specific pathological states. The oncogenic RAS-selective lethal small …

In the mammalian central nervous system, reactive oxygen species (ROS) generation is
counterbalanced by antioxidant defenses. When large amounts of ROS accumulate …

Ferroptosis is mechanism for non-apoptotic, iron-dependent, oxidative cell death that is
characterized by glutathione consumption and lipid peroxides accumulation. Ferroptosis is …

Cerebrovascular diseases, such as ischemic stroke, pose serious medical challenges
worldwide due to their high morbidity and mortality and limitations in clinical treatment …

The basic role of metal ions including copper, zinc and iron in neurological pathologies is
generally accepted. The relationship between the development of disease and particular …

Nitric oxide (NO), a free gaseous signaling molecule, is involved in the regulation of the
cardiovascular, nervous and immune system. The neurotransmitter function of nitric oxide is …