Computational tools for modern vaccine development

Sunita, A Sajid, Y Singh, P Shukla - Human vaccines & …, 2020 - Taylor & Francis
Vaccines play an essential role in controlling the rates of fatality and morbidity. Vaccines not
only arrest the beginning of different diseases but also assign a gateway for its elimination …

Advances in in-silico B-cell epitope prediction

P Sun, S Guo, J Sun, L Tan, C Lu… - Current Topics in …, 2019 - ingentaconnect.com
Identification of B-cell epitopes in target antigens is one of the most crucial steps for
epitopebased vaccine development, immunodiagnostic tests, antibody production, and …

Vaccinomics-based next-generation multi-epitope chimeric vaccine models prediction against Leishmania tropica - a hierarchical subtractive proteomics and …

S Aiman, A Ahmad, AA Khan, AM Alanazi… - Frontiers in …, 2023 - frontiersin.org
Leishmania tropica is a vector-borne parasitic protozoa that is the leading cause of
leishmaniasis throughout the global tropics and subtropics. L. tropica is a multidrug-resistant …

Immunoinformatics-based potential multi-peptide vaccine designing against Jamestown Canyon Virus (JCV) capable of eliciting cellular and humoral immune …

M Shahab, S Aiman, A Alshammari, AF Alasmari… - International Journal of …, 2023 - Elsevier
Jamestown Canyon virus (JCV) is a deadly viral infection transmitted by various mosquito
species. This mosquito-borne virus belongs to Bunyaviridae family, posing a high public …

In silico designing of a multi-epitope vaccine against Burkholderia pseudomallei: Reverse vaccinology and immunoinformatics

M Shahab, C Hayat, R Sikandar, G Zheng… - Journal of Genetic …, 2022 - Elsevier
Background Burkholderia pseudomallei is an infectious agent causing severe disease
melioidosis resulting in pneumonia, fever, and acute septicemia in humans. B. pseudomallei …

Vaccinomics-aided next-generation novel multi-epitope-based vaccine engineering against multidrug resistant Shigella Sonnei: Immunoinformatics and …

S Aiman, A Ahmad, A Khan, Y Ali, A Malik, M Alkholief… - Plos one, 2023 - journals.plos.org
Shigella sonnei is a gram-negative bacterium and is the primary cause of shigellosis in
advanced countries. An exceptional rise in the prevalence of the disease has been reported …

iLBE for computational identification of linear B-cell epitopes by integrating sequence and evolutionary features

MM Hasan, MS Khatun, H Kurata - Genomics, Proteomics and …, 2020 - academic.oup.com
Linear B-cell epitopes are critically important for immunological applications, such as
vaccine design, immunodiagnostic test, and antibody production, as well as disease …

Inferring linear-B cell epitopes using 2-step metaheuristic variant-feature selection using genetic algorithm

P Angaitkar, T Aljrees, S Kumar Pandey, A Kumar… - Scientific Reports, 2023 - nature.com
Linear-B cell epitopes (LBCE) play a vital role in vaccine design; thus, efficiently detecting
them from protein sequences is of primary importance. These epitopes consist of amino …

Design of an epitope-based vaccine ensemble for animal trypanosomiasis by computational methods

L Michel-Todó, P Bigey, PA Reche, MJ Pinazo… - Vaccines, 2020 - mdpi.com
African animal trypanosomiasis is caused by vector-transmitted parasites of the genus
Trypanosoma. T. congolense and T. brucei brucei are predominant in Africa; T. evansi and …

The history of anti-trypanosome vaccine development shows that highly immunogenic and exposed pathogen-derived antigens are not necessarily good target …

S Magez, Z Li, HTT Nguyen, JE Pinto Torres… - Pathogens, 2021 - mdpi.com
Salivarian trypanosomes comprise a group of extracellular anthroponotic and zoonotic
parasites. The only sustainable method for global control of these infection is through …