Computational tools for modern vaccine development
Vaccines play an essential role in controlling the rates of fatality and morbidity. Vaccines not
only arrest the beginning of different diseases but also assign a gateway for its elimination …
only arrest the beginning of different diseases but also assign a gateway for its elimination …
Advances in in-silico B-cell epitope prediction
P Sun, S Guo, J Sun, L Tan, C Lu… - Current Topics in …, 2019 - ingentaconnect.com
Identification of B-cell epitopes in target antigens is one of the most crucial steps for
epitopebased vaccine development, immunodiagnostic tests, antibody production, and …
epitopebased vaccine development, immunodiagnostic tests, antibody production, and …
Vaccinomics-based next-generation multi-epitope chimeric vaccine models prediction against Leishmania tropica - a hierarchical subtractive proteomics and …
Leishmania tropica is a vector-borne parasitic protozoa that is the leading cause of
leishmaniasis throughout the global tropics and subtropics. L. tropica is a multidrug-resistant …
leishmaniasis throughout the global tropics and subtropics. L. tropica is a multidrug-resistant …
Immunoinformatics-based potential multi-peptide vaccine designing against Jamestown Canyon Virus (JCV) capable of eliciting cellular and humoral immune …
M Shahab, S Aiman, A Alshammari, AF Alasmari… - International Journal of …, 2023 - Elsevier
Jamestown Canyon virus (JCV) is a deadly viral infection transmitted by various mosquito
species. This mosquito-borne virus belongs to Bunyaviridae family, posing a high public …
species. This mosquito-borne virus belongs to Bunyaviridae family, posing a high public …
In silico designing of a multi-epitope vaccine against Burkholderia pseudomallei: Reverse vaccinology and immunoinformatics
M Shahab, C Hayat, R Sikandar, G Zheng… - Journal of Genetic …, 2022 - Elsevier
Background Burkholderia pseudomallei is an infectious agent causing severe disease
melioidosis resulting in pneumonia, fever, and acute septicemia in humans. B. pseudomallei …
melioidosis resulting in pneumonia, fever, and acute septicemia in humans. B. pseudomallei …
Vaccinomics-aided next-generation novel multi-epitope-based vaccine engineering against multidrug resistant Shigella Sonnei: Immunoinformatics and …
Shigella sonnei is a gram-negative bacterium and is the primary cause of shigellosis in
advanced countries. An exceptional rise in the prevalence of the disease has been reported …
advanced countries. An exceptional rise in the prevalence of the disease has been reported …
iLBE for computational identification of linear B-cell epitopes by integrating sequence and evolutionary features
Linear B-cell epitopes are critically important for immunological applications, such as
vaccine design, immunodiagnostic test, and antibody production, as well as disease …
vaccine design, immunodiagnostic test, and antibody production, as well as disease …
Inferring linear-B cell epitopes using 2-step metaheuristic variant-feature selection using genetic algorithm
Linear-B cell epitopes (LBCE) play a vital role in vaccine design; thus, efficiently detecting
them from protein sequences is of primary importance. These epitopes consist of amino …
them from protein sequences is of primary importance. These epitopes consist of amino …
Design of an epitope-based vaccine ensemble for animal trypanosomiasis by computational methods
L Michel-Todó, P Bigey, PA Reche, MJ Pinazo… - Vaccines, 2020 - mdpi.com
African animal trypanosomiasis is caused by vector-transmitted parasites of the genus
Trypanosoma. T. congolense and T. brucei brucei are predominant in Africa; T. evansi and …
Trypanosoma. T. congolense and T. brucei brucei are predominant in Africa; T. evansi and …
The history of anti-trypanosome vaccine development shows that highly immunogenic and exposed pathogen-derived antigens are not necessarily good target …
S Magez, Z Li, HTT Nguyen, JE Pinto Torres… - Pathogens, 2021 - mdpi.com
Salivarian trypanosomes comprise a group of extracellular anthroponotic and zoonotic
parasites. The only sustainable method for global control of these infection is through …
parasites. The only sustainable method for global control of these infection is through …