During Parkinson's disease (PD), both the central nervous system (CNS) and peripheral
nervous system (PNS) are affected. In parallel, innate immune cells respond early to …

Protein misfolding and accumulation defines a prevailing feature of many
neurodegenerative disorders, finally resulting in the formation of toxic intra-and extracellular …

Background Variants in the CTSB gene encoding the lysosomal hydrolase cathepsin B
(catB) are associated with increased risk of Parkinson's disease (PD). However, neither the …

In Parkinson's disease (PD), and other α-synucleinopathies, α-synuclein (α-Syn) aggregates
form a myriad of conformational and truncational variants. Most antibodies used to detect …

Misfolded α-synuclein (α-syn) is believed to contribute to neurodegeneration in Lewy body
disease (LBD) based on considerable evidence including a gene-dosage effect observed in …

Recently, proposals have attempted to reclassify Lewy body diseases in vivo by merging the
long-established clinicopathological entities of Parkinson's disease (PD), Parkinson's …

Parkinson's disease (PD) and multiple system atrophy (MSA) are classified as α-
synucleinopathies and are primarily differentiated by their clinical phenotypes. Delineating …

Background Parkinson's disease (PD) is associated with cognitive decline through multiple
mechanisms, including Alzheimer's disease (AD) pathology and cortical Lewy body …

Amyloid fibrils of proteins such as α-synuclein are a hallmark of neurodegenerative diseases
and much research has focused on their kinetics and mechanisms of formation. The …

Posttranslational modifications (PTMs) of proteins play central roles in regulating the protein
structure, interactome, and functions. A notable modification site is the aromatic side chain of …