TGF-β plays a prominent role as an inducer of epithelial-mesenchymal transitions (EMTs)
during development and wound healing and in disease conditions such as fibrosis and …

TGF-β signaling controls a plethora of cellular responses and figures prominently in animal
development. Recent cellular, biochemical, and structural studies have revealed significant …

Smad transcription factors lie at the core of one of the most versatile cytokine signaling
pathways in metazoan biology—the transforming growth factor-β (TGFβ) pathway. Recent …

The deployment of a cell's genetic program in a multicellular organism must be tightly
controlled for the sake of the organism as a whole. Over the past 20 years the transforming …

Members of the TGF-β superfamily, which includes TGF-βs, growth differentiation factors,
bone morphogenetic proteins, activins, inhibins, and glial cell line-derived neurotrophic …

Signaling from transforming growth factor-β (TGF-β) through its unique transmembrane
receptor serine–threonine kinases plays a complex role in carcinogenesis, having both …

Transforming growth factor‐β (TGF‐β) family members which include TGF‐βs, activins, and
bone morphogenetic proteins (BMPs) regulate a broad spectrum of biological responses on …

Ectopic expression of combinations of transcription factors (TFs) can drive direct lineage
conversion, thereby reprogramming a somatic cell's identity. To determine the molecular …

It has been 70 years since the name inhibin was used to describe a gonadal factor that
negatively regulated pituitary hormone secretion. The majority of this period was required to …

Holoprosencephaly (HPE) is the most common structural defect of the developing forebrain
in humans (1 in 250 conceptuses, 1 in 16,000 live-born infants 1, 2, 3). HPE is aetiologically …