Aging is characterized by systemic chronic inflammation, which is accompanied by cellular
senescence, immunosenescence, organ dysfunction, and age-related diseases. Given the …

Dietary restriction with adequate nutrition is the gold standard for delaying ageing and
extending healthspan and lifespan in diverse species, including rodents and non-human …

Healthy aging and human longevity are intricate phenotypes affected by environmental
factors such as physical exercise, diet, health habits, and psychosocial situations as well as …

Lifespan varies within and across species, but the general principles of its control remain
unclear. Here, we conducted multi-tissue RNA-seq analyses across 41 mammalian species …

Aging is an inevitable outcome of life, characterized by progressive decline in tissue and
organ function and increased risk of mortality. Accumulating evidence links aging to genetic …

Calorie restriction or changes in dietary composition can enhance healthy aging, but the
inability of most subjects to adhere to chronic and extreme diets, as well as potentially …

Aging is a major risk factor for a number of chronic diseases, including neurodegenerative
and cerebrovascular disorders. Aging processes have therefore been discussed as potential …

Recent research suggests that epigenetics, especially DNA methylation, plays a mechanistic
role in aging. Epigenetic clocks, which measure changes in a few hundred specific CpG …

Answering the question as to why we age is tantamount to answering the question of what is
life itself. There are countless theories as to why and how we age, but, until recently, the very …

The DNA methylation levels of certain CpG sites are thought to reflect the pace of human
aging. Here, we developed a robust predictor of mouse biological age based on 90 CpG …