Emerging mechanistic understanding of cilia function in cellular signalling
Primary cilia are solitary, immotile sensory organelles present on most cells in the body that
participate broadly in human health, physiology and disease. Cilia generate a unique …
participate broadly in human health, physiology and disease. Cilia generate a unique …
Mutations in G protein–coupled receptors: mechanisms, pathophysiology and potential therapeutic approaches
T Schöneberg, I Liebscher - Pharmacological reviews, 2021 - ASPET
There are approximately 800 annotated G protein–coupled receptor (GPCR) genes, making
these membrane receptors members of the most abundant gene family in the human …
these membrane receptors members of the most abundant gene family in the human …
Common activation mechanism of class A GPCRs
Class A G-protein-coupled receptors (GPCRs) influence virtually every aspect of human
physiology. Understanding receptor activation mechanism is critical for discovering novel …
physiology. Understanding receptor activation mechanism is critical for discovering novel …
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome
G-protein-coupled receptors (GPCRs) remain major drug targets, despite our incomplete
understanding of how they signal through 16 non-visual G-protein signal transducers …
understanding of how they signal through 16 non-visual G-protein signal transducers …
[HTML][HTML] A global map of G protein signaling regulation by RGS proteins
The control over the extent and timing of G protein signaling is provided by the regulator of G
protein signaling (RGS) proteins that deactivate G protein α subunits (Gα). Mammalian …
protein signaling (RGS) proteins that deactivate G protein α subunits (Gα). Mammalian …
Dynamic spatiotemporal determinants modulate GPCR: G protein coupling selectivity and promiscuity
Recent studies have shown that G protein coupled receptors (GPCRs) show selective and
promiscuous coupling to different Gα protein subfamilies and yet the mechanisms of the …
promiscuous coupling to different Gα protein subfamilies and yet the mechanisms of the …
Ligand recognition and G-protein coupling selectivity of cholecystokinin A receptor
Cholecystokinin A receptor (CCKAR) belongs to family A G-protein-coupled receptors and
regulates nutrient homeostasis upon stimulation by cholecystokinin (CCK). It is an attractive …
regulates nutrient homeostasis upon stimulation by cholecystokinin (CCK). It is an attractive …
Structural basis of Gs and Gi recognition by the human glucagon receptor
A Qiao, S Han, X Li, Z Li, P Zhao, A Dai, R Chang, L Tai… - Science, 2020 - science.org
Class BG protein–coupled receptors, an important class of therapeutic targets, signal mainly
through the Gs class of heterotrimeric G proteins, although they do display some promiscuity …
through the Gs class of heterotrimeric G proteins, although they do display some promiscuity …
Subcellular location defines GPCR signal transduction
A Radoux-Mergault, L Oberhauser, S Aureli… - Science …, 2023 - science.org
Intracellular G protein-coupled receptors (GPCRs) can be activated by permeant ligands,
which contributes to agonist selectivity. Opioid receptors (ORs) provide a notable example …
which contributes to agonist selectivity. Opioid receptors (ORs) provide a notable example …
The role of G protein conformation in receptor–G protein selectivity
G protein-coupled receptors (GPCRs) selectively activate at least one of the four families of
heterotrimeric G proteins, but the mechanism of coupling selectivity remains unclear …
heterotrimeric G proteins, but the mechanism of coupling selectivity remains unclear …