Huntington's disease (HD) is a devastating monogenic neurodegenerative disease
characterized by early, selective pathology in the basal ganglia despite the ubiquitous …

Huntington's disease is a genetic neurodegenerative disorder. White matter alterations have
recently been identified as a relevant pathophysiological feature of Huntington's disease, but …

Huntington's disease (HD) is an autosomal dominant disorder caused by an expansion in
the trinucleotide CAG repeat in exon-1 in the huntingtin gene, located on chromosome 4 …

Huntington's disease (HD) is characterized by defective oligodendroglial differentiation and
white matter disease. Here, we investigate the role of oligodendrocyte progenitor cell (OPC) …

Objective Machado–Joseph disease (SCA3/MJD) is the most frequent spinocerebellar
ataxia worldwide and characterized by brainstem, basal ganglia, and cerebellar damage …

Background The earliest white matter changes in Huntington's disease are seen before
disease onset in the premanifest stage around the striatum, within the corpus callosum, and …

Trans‐neuronal propagation of mutant huntingtin protein contributes to the organised
spread of cortico‐striatal degeneration and disconnection in Huntington's disease (HD). We …

While it is well known that the vestibular system is responsible for maintaining balance,
posture and coordination, there is increasing evidence that it also plays an important role in …

Huntington's disease is a devastating neurodegenerative disorder that onsets in late
adulthood as progressive and terminal cognitive, psychiatric and motor deficits. The disease …

We lack a mechanistic explanation for the stereotyped pattern of white matter loss seen in
Huntington's disease (HD). While the earliest white matter changes are seen around the …