Cellular signaling networks are the foundation which determines the fate and function of
cells as they respond to various cues and stimuli. The discovery of fluorescent proteins over …

Experimental efforts to understand how the brain represents, stores and processes
information require high-fidelity recordings of multiple different forms of neural activity within …

Reversibly photo-switchable proteins are essential for many super-resolution fluorescence
microscopic and optoacoustic imaging methods. However, they have yet to be used as …

Biosensors are powerful tools for detecting, real-time imaging, and quantifying molecules,
but rapidly constructing diverse genetically encoded biosensors remains challenging. Here …

We review the principles of development and deployment of genetically encoded calcium
indicators (GECIs) for the detection of neural activity. Our focus is on the popular GCaMP …

Billions of US dollars are invested every year by the pharmaceutical industry in drug
development, with the aim of introducing new drugs that are effective and have minimal side …

Calmodulin-based genetically encoded fluorescent calcium indicators (GCaMP-s) are
powerful tools of imaging calcium dynamics from cells to freely moving animals. High affinity …

Confirming the direct link between neural circuit activity and animal behavior has been a
principal aim of neuroscience. The genetically encoded calcium indicator (GECI), which …

Neural circuits and the cells that comprise them represent the functional units of the brain.
Circuits relay and process sensory information, maintain homeostasis, drive behaviors, and …

The response of endothelial cells to signaling stimulation is critical for vascular
morphogenesis, homeostasis and function. Vascular endothelial growth factor-a (VEGFA) …