Lactate in the brain has long been associated with ischaemia; however, more recent
evidence shows that it can be found there under physiological conditions. In the brain …

The energy requirements of the brain are very high, and tight regulatory mechanisms
operate to ensure adequate spatial and temporal delivery of energy substrates in register …

Monocarboxylate transporters (MCTs) constitute a family of 14 members among which
MCT1–4 facilitate the passive transport of monocarboxylates such as lactate, pyruvate and …

Breakthrough technologies to measure cellular oxygen consumption and proton efflux are
reigniting the study of cellular energetics by increasing the scope and pace with which …

The immunogenic demise of cancer cells can be induced by various chemotherapeutics,
such as anthracyclines and oxaliplatin, and provokes an immune response against tumor …

Since its introduction 16 years ago, the astrocyte–neuron lactate shuttle (ANLS) model has
profoundly modified our understanding of neuroenergetics by bringing a cellular and …

The ATP: ADP ratio is a critical parameter of cellular energy status that regulates many
metabolic activities. Here we report an optimized genetically encoded fluorescent biosensor …

For much of the 20th century, lactate was largely considered a dead‐end waste product of
glycolysis due to hypoxia, the primary cause of the O2 debt following exercise, a major …

Glucose is the mandatory fuel for the brain, yet the relative contribution of glucose and
lactate for neuronal energy metabolism is unclear. We found that increased lactate, but not …

Astrocytes play a critical role in the regulation of brain metabolic responses to activity. One
detailed mechanism proposed to describe the role of astrocytes in some of these responses …