CD44: a multifunctional mediator of cancer progression

M Hassn Mesrati, SE Syafruddin, MA Mohtar, A Syahir - Biomolecules, 2021 - mdpi.com
CD44, a non-kinase cell surface transmembrane glycoprotein, has been widely implicated
as a cancer stem cell (CSC) marker in several cancers. Cells overexpressing CD44 possess …

The role of non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential

X Meng, QY Lou, WY Yang, YR Wang… - Cancer …, 2021 - Wiley Online Library
Oral squamous cell carcinoma (OSCC), the eighth most prevalent cancer in the world, arises
from the interaction of multiple factors including tobacco, alcohol consumption, and betel …

Novel prognostic clinical factors and biomarkers for outcome prediction in head and neck cancer: a systematic review

V Budach, I Tinhofer - The Lancet Oncology, 2019 - thelancet.com
Current algorithms for the clinical management of patients with squamous cell carcinoma of
the head and neck (HNSCC) are based on a stage-dependent strategy where all patients at …

The role of ABC transporters in ovarian cancer progression and chemoresistance

MP Ween, MA Armstrong, MK Oehler… - Critical reviews in …, 2015 - Elsevier
Over 80% of ovarian cancer patients develop chemoresistance which results in a lethal
course of the disease. A well-established cause of chemoresistance involves the family of …

Cancer stem cells in oral cavity squamous cell carcinoma: a review

R Baillie, ST Tan, T Itinteang - Frontiers in Oncology, 2017 - frontiersin.org
Cancer stem cells (CSCs) have been identified in oral cavity squamous cell carcinoma
(OCSCC). CSCs possess the ability for perpetual self-renewal and proliferation, producing …

[HTML][HTML] Induction chemotherapy in locally advanced squamous cell carcinoma of the head and neck: role, controversy, and future directions

RI Haddad, M Posner, R Hitt, EEW Cohen, J Schulten… - Annals of …, 2018 - Elsevier
Background The value of induction chemotherapy (ICT) remains under investigation despite
decades of research. New advancements in the field, specifically regarding the induction …

Unraveling the journey of cancer stem cells from origin to metastasis

RK Nimmakayala, SK Batra, MP Ponnusamy - Biochimica et Biophysica …, 2019 - Elsevier
Cancer biology research over recent decades has given ample evidence for the existence of
self-renewing and drug-resistant populations within heterogeneous tumors, widely …

Crosstalk between Raf-MEK-ERK and PI3K-Akt-GSK3β signaling networks promotes chemoresistance, invasion/migration and stemness via expression of CD44 …

T Kashyap, KK Pramanik, N Nath, P Mishra, AK Singh… - Oral oncology, 2018 - Elsevier
Background The cell-surface glycoprotein CD44 is an important oral cancer stem cell
(OCSC) marker and plays significant role in oral squamous cell carcinoma (OSCC) …

Cancer stem cells: an insight into the development of metastatic tumors and therapy resistance

T Nairuz, Z Mahmud, RK Manik, Y Kabir - Stem Cell Reviews and Reports, 2023 - Springer
The term “cancer stem cells”(CSCs) refers to cancer cells that exhibit traits parallel to normal
stem cells, namely the potential to give rise to every type of cell identified in a tumor …

Oral cancer stem cells: Therapeutic implications and challenges

LA Shahoumi - Frontiers in Oral Health, 2021 - frontiersin.org
Head and neck squamous cell carcinoma (HNSCC) is currently one of the 10 most common
malignancies worldwide, characterized by a biologically highly diverse group of tumors with …