Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of
Parkinson's disease (PD) is now twenty-five years old, it still represents a milestone in PD …

Alzheimer's disease (AD) is a neurodegenerative disorder molecularly characterized by the
formation of amyloid β (Aβ) plaques and type 2 microtubule-associated protein (Tau) …

The neurovascular unit (NVU) is composed of vascular cells, glial cells, and neurons. As a
fundamental functional module in the central nervous system, the NVU maintains …

Nearly half of all adults older than 60 years of age report sleep disturbance, as characterised
either by reports of insomnia complaints with daytime consequences, dissatisfaction with …

In the past decade, numerous studies have demonstrated the close relationship between gut
microbiota and the occurrence and development of Alzheimer's disease (AD). However, the …

Cerebrospinal fluid analyses and neuroimaging can identify the underlying pathophysiology
at the earliest stage of some neurodegenerative disorders, but do not have the scalability …

Alzheimer's disease (AD) is a neurodegenerative disease with unknown pathogenesis and
complex pathological manifestations. At present, a large number of studies on targeted …

Neuroinflammation regulated by microglia is one of the important factors involved in the
pathogenesis of Alzheimer's disease (AD). Activated microglia exhibited phenotypes termed …

Background The development of mild cognitive impairment (MCI) and Alzheimer's disease
(AD) may be associated with an inflammatory process. Inflammatory cytokines may be a …

Spinal cord injury (SCI), as one of the intractable diseases in clinical medicine, affects
thousands of human beings, and the pathologic changes after injury have been a hot spot …