Malaria in pregnancy: from placental infection to its abnormal development and damage

CLL Chua, SKM Khoo, JLE Ong… - Frontiers in …, 2021 - frontiersin.org
Malaria remains a global health burden with Plasmodium falciparum accounting for the
highest mortality and morbidity. Malaria in pregnancy can lead to the development of …

Poor birth outcomes in malaria in pregnancy: recent insights into mechanisms and prevention approaches

CLL Chua, W Hasang, SJ Rogerson, A Teo - Frontiers in immunology, 2021 - frontiersin.org
Pregnant women in malaria-endemic regions are susceptible to malaria in pregnancy, which
has adverse consequences on birth outcomes, including having small for gestational age …

Systems biology of malaria explored with nonhuman primates

MR Galinski - Malaria journal, 2022 - Springer
Abstract “The Primate Malarias” book has been a uniquely important resource for multiple
generations of scientists, since its debut in 1971, and remains pertinent to the present day …

Progress and insights toward an effective placental malaria vaccine

B Gamain, A Chêne, NK Viebig… - Frontiers in …, 2021 - frontiersin.org
In areas where Plasmodium falciparum transmission is endemic, clinical immunity against
malaria is progressively acquired during childhood and adults are usually protected against …

Progress and new horizons toward a VAR2CSA-based placental malaria vaccine

JYA Doritchamou, J Suurbaar… - Expert Review of …, 2021 - Taylor & Francis
Introduction: Several malaria vaccines are under various phases of development with some
promising results. In placental malaria (PM) a deliberately anti-disease approach is …

Dynamics of Plasmodium berghei NK-65 parasitaemia and CD3+CD4+CD25+Fox-p3+ T-regulatory cells in experimentally induced malaria during early, mid, and …

PL Manhas, M Sharma, A Mewara… - Indian Journal of …, 2023 - Springer
Introduction Malaria in pregnancy causes a dual brunt on the mother as well as the foetus.
Upregulation of T-regulatory cells (Tregs) during pregnancy allows tolerance towards the …

Plasmodium falciparum in Aotus nancymaae: A New Model for Placental Malaria

A Sharma, B Jenkins, A Akue… - The Journal of …, 2022 - academic.oup.com
Plasmodium falciparum-infected erythrocytes that display the variant surface antigen
VAR2CSA bind chondroitin sulfate A (CSA) to sequester in placental intervillous spaces …

[HTML][HTML] Asymptomatic malaria infection and its associated factors among pregnant women in Ethiopia; a systematic review and meta-analysis

GA Kassie, GA Azeze, AY Gebrekidan… - Parasite Epidemiology …, 2024 - Elsevier
Background Asymptomatic malaria during pregnancy is a significant public health concern
in malaria-endemic regions, which worsens the various effects of malaria on the mother and …

Contribution of murine models to the study of malaria during pregnancy

A Barateiro, MLM Pereira, S Epiphanio… - Frontiers in …, 2019 - frontiersin.org
Annually, many pregnancies occur in areas of Plasmodium spp. transmission, particularly in
underdeveloped countries with widespread poverty. Estimations have suggested that …

Potential pharmacologic interventions targeting TLR signaling in placental malaria

FM Kobia, K Maiti, MM Obimbo, R Smith, J Gitaka - Trends in parasitology, 2022 - cell.com
Complications from placental malaria cause poor pregnancy outcomes, including low
birthweight, preterm delivery, and stillbirths. Many of these complications are driven by …