Critical review of exposure and effects: implications for setting regulatory health criteria for ingested copper
AA Taylor, JS Tsuji, MR Garry, ME McArdle… - Environmental …, 2020 - Springer
Decades of study indicate that copper oral exposures are typically not a human health
concern. Ingesting high levels of soluble copper salts can cause acute gastrointestinal …
concern. Ingesting high levels of soluble copper salts can cause acute gastrointestinal …
The multifaceted roles of copper in cancer: A trace metal element with dysregulated metabolism, but also a target or a bullet for therapy
Simple Summary Copper is an essential element for human life. However, its redox activity
can be detrimental for the cell that developed highly coordinated pathways to chelate and …
can be detrimental for the cell that developed highly coordinated pathways to chelate and …
A multidisciplinary approach to the diagnosis and management of Wilson disease: Executive summary of the 2022 Practice Guidance on Wilson disease from the …
ML Schilsky, EA Roberts, JM Bronstein, A Dhawan… - Hepatology, 2023 - journals.lww.com
Copper is an essential metal required for many metalloproteins' function. A fraction of dietary
copper (average 2–5 mg/day) is absorbed by enterocytes in the duodenum and proximal …
copper (average 2–5 mg/day) is absorbed by enterocytes in the duodenum and proximal …
The molecular mechanisms of copper metabolism and its roles in human diseases
J Chen, Y Jiang, H Shi, Y Peng, X Fan, C Li - Pflügers Archiv-European …, 2020 - Springer
Copper is an essential element in cells; it can act as either a recipient or a donor of
electrons, participating in various reactions. However, an excess of copper ions in cells is …
electrons, participating in various reactions. However, an excess of copper ions in cells is …
Haemochromatosis
P Brissot, A Pietrangelo, PC Adams… - Nature reviews Disease …, 2018 - nature.com
Haemochromatosis is defined as systemic iron overload of genetic origin, caused by a
reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in …
reduction in the concentration of the iron regulatory hormone hepcidin, or a reduction in …
Overview of iron metabolism in health and disease
Iron is an essential element for numerous fundamental biologic processes, but excess iron is
toxic. Abnormalities in systemic iron balance are common in patients with chronic kidney …
toxic. Abnormalities in systemic iron balance are common in patients with chronic kidney …
[HTML][HTML] Iron homeostasis during pregnancy
AL Fisher, E Nemeth - The American journal of clinical nutrition, 2017 - Elsevier
During pregnancy, iron needs to increase substantially to support fetoplacental development
and maternal adaptation to pregnancy. To meet these iron requirements, both dietary iron …
and maternal adaptation to pregnancy. To meet these iron requirements, both dietary iron …
The multifaceted role of iron in renal health and disease
RPL van Swelm, JFM Wetzels… - Nature Reviews …, 2020 - nature.com
Iron is an essential element that is indispensable for life. The delicate physiological body
iron balance is maintained by both systemic and cellular regulatory mechanisms. The iron …
iron balance is maintained by both systemic and cellular regulatory mechanisms. The iron …
Liver iron sensing and body iron homeostasis
The liver orchestrates systemic iron balance by producing and secreting hepcidin. Known as
the iron hormone, hepcidin induces degradation of the iron exporter ferroportin to control …
the iron hormone, hepcidin induces degradation of the iron exporter ferroportin to control …