The malignant tumor is a multi-etiological, systemic and complex disease characterized by
uncontrolled cell proliferation and distant metastasis. Anticancer treatments including …

The most abundant cell type in the tumor microenvironment are cancer-associated
fibroblasts (CAFs). CAFs play an important role in tumor growth and progression. Besides …

Purpose To investigate the role of neutrophil extracellular traps (NETs) and NET-associated
proteins in the pathogenesis of oGVHD and whether dismantling of NETs with heparin …

Evidence is increasing on the crucial role of the extracellular matrix (ECM) in breast cancer
progression, invasion and metastasis with almost all mortality cases owing to metastasis …

Desmoplasia, a fibrotic mass including cancer-associated fibroblasts (CAFs) and self-
sustaining extracellular matrix (D-ECM), is a puzzling feature of pancreatic ductal …

Simple Summary Breast cancer is the most common diagnosed malignancy and the main
leading cause of tumor-related death among women worldwide. Thus, several studies have …

Background: Currently, there are no molecular biomarkers for the early detection of non-
small-cell lung cancer (NSCLC). This study focused on identifying RNAs found on tumor …

Background: The tumor microenvironment (TME) represents the many components
occupying the space within and surrounding a tumor, including cells, signaling factors …

The tumor microenvironment is crucial in the initiation and progression of cancers. The
interplay between cancer cells and the surrounding stroma shapes the tumor biology and …

There is currently an increased interest in understanding the role of the tumor
microenvironment (TME) in tumor growth and progression. In this context the role of integrins …