Abstract Interleukin-17 (IL-17)-producing helper T (TH17) cells are heterogenous and
consist of nonpathogenic TH17 (npTH17) cells that contribute to tissue homeostasis and …

Stem‐like T cells are characterized by their ability to self‐renew, survive long‐term, and give
rise to a heterogeneous pool of effector and memory T cells. Recent advances in single‐cell …

Sepsis-associated encephalopathy (SAE) is common in septic patients, characterized by
acute and long-term cognitive impairment, and is associated with higher mortality. This study …

Proinflammatory TREM1 receptors expressed on myeloid-derived cells have recently been
recognized as a new oncogenic target in cancer, including gliomas. They are established …

Objective Pancreatic ductal adenocarcinoma (PDAC) has limited therapeutic options,
particularly with immune checkpoint inhibitors. Highly chemoresistant 'stem-like'cells, known …

Peptidoglycan recognition proteins (PGRPs or PGLYRPs) are implicated in the control of the
intestinal microbiota; however, molecular requirements for peptidoglycan (PGN) binding and …

Background and Objectives: Multiple sclerosis (MS) is a chronic autoimmune disease with
limited treatment options. Thus, drug discovery and repurposing are essential to enhance …

Background: The gut microbiome is an important contributor to the development and the
course of inflammatory bowel disease (IBD). While changes in the gut microbiome …

Neuroinflammation has been identified as a crucial element in several neurological
disorders. Glial cells play a critical role in directing neuroinflammation, both in deleterious …

Background Triple-negative breast cancers (TNBC) occur more frequently in African
Americans and are associated with worse outcomes when compared to other subtypes of …