Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface
to activate canonical or non-canonical Wnt signaling pathways, which control various …

Collective cell migration has a key role during morphogenesis and during wound healing
and tissue renewal in the adult, and it is involved in cancer spreading. In addition to …

Planar cell polarity (PCP) is an essential feature of animal tissues, whereby distinct polarity
is established within the plane of a cell sheet. Tissue-wide establishment of PCP is driven by …

Idiopathic scoliosis (IS) affects 3% of children worldwide, yet the mechanisms underlying this
spinal deformity remain unknown. Here we show that ptk7 mutant zebrafish, a faithful …

Cellular senescence and the senescence-associated secretory phenotype (SASP) are
implicated in aging and age-related disease, and SASP-related inflammation is thought to …

Abstract Protein tyrosine kinase 7 (PTK7) and cancer-associated fibroblasts (CAFs) play
important roles in cancer stemness, respectively. However, little is known about interaction …

Scoliosis is a complex genetic disorder of the musculoskeletal system, characterized by
three-dimensional rotation of the spine. Curvatures caused by malformed vertebrae …

Gastrulation and neurulation are successive morphogenetic processes that play key roles in
shaping the basic embryonic body plan. Importantly, they operate through common cellular …

Disease relapse after treatment is common in triple-negative breast cancer (TNBC), ovarian
cancer (OVCA), and non–small cell lung cancer (NSCLC). Therapies that target tumor …

The planar cell polarity (PCP) pathway is best known for its role in polarizing epithelial cells
within the plane of a tissue but it also plays a role in a range of cell migration events during …