Decreased skeletal muscle contractile activity (disuse) or unloading leads to muscle mass
loss, also known as muscle atrophy. The balance between muscle protein synthesis (MPS) …

Given its pivotal role in fatty acid oxidation and energy metabolism, l-carnitine has been
investigated as ergogenic aid for enhancing exercise capacity in the healthy athletic …

Sarcopenia is the loss of muscle mass, strength, and physical function that is characteristic
of aging. The progression of sarcopenia is gradual but may be accelerated by periods of …

Skeletal muscle atrophy is a debilitating condition that occurs with aging and disease, but
the underlying mechanisms are incompletely understood. Previous work determined that …

Aging is characterized by loss of proteostasis and mitochondrial homeostasis. Here, we
provide bioinformatic evidence of dysregulation of mitochondrial and proteostasis pathways …

Aging is a complex phenomenon that has detrimental effects on tissue homeostasis. The
skeletal muscle is one of the earliest tissues to be affected and to manifest age-related …

Most eukaryotic proteins are N-terminally acetylated, but the functional impact on a global
scale has remained obscure. Using genome-wide CRISPR knockout screens in human …

Ageing is a complex biological process associated with increased morbidity and mortality.
Nine classic, interdependent hallmarks of ageing have been proposed involving genetic and …

During aging, proteostasis capacity declines and distinct proteins become unstable and can
accumulate as protein aggregates inside and outside of cells. Both in disease and during …

Alzheimer's disease (AD) is the most frequent cause of dementia. After decades of research,
we know the importance of the accumulation of protein aggregates such as β-amyloid …