Immunotherapy of Clear-Cell Renal-Cell Carcinoma

S Grigolo, L Filgueira - Cancers, 2024 - mdpi.com
Simple Summary Immunotherapeutic synergy represents the cornerstone of the treatment
intended for patients with clear-cell renal-cell carcinoma. In most cases, this type of cancer …

Digital spatial profiling identifies the tumor center as a topological niche in prostate cancer characterized by an upregulation of BAD

AK Huber, A Kaczorowski, F Schneider, S Böning… - Scientific Reports, 2024 - nature.com
Prostate cancer is characterized by a high degree of intratumoral heterogeneity. However,
little is known about the spatial distribution of cancer cells with respect to specific functional …

[PDF][PDF] Impelling Times for Tissue Section Proteomics in Cancer

AA Ahmed, A Ouban - 2024 - cellnatsci.com
Cancer drug development in the modern era focuses on identifying inhibitors of gene
products directly involved in the pathogenesis of cancers. These new molecularly targeted …

Region of interest localization, tissue storage time and antibody binding density–a technical note on the GeoMx® Digital Spatial Profiler

S Böning, F Schneider, AK Huber, D Langhoff… - Immuno-Oncology and …, 2024 - Elsevier
Spatial biology is an emerging concept to interrogate tumor heterogeneity. The NanoString
GeoMx® Digital Spatial Profiling (DSP) platform has become increasingly available. It …