Tau and amyloid beta (Aβ) are the prime suspects for driving pathology in Alzheimer's
disease (AD) and, as such, have become the focus of therapeutic development. Recent …

Microtubule-associated proteins (MAPs) were initially discovered as proteins that bind to
and stabilize microtubules. Today, an ever-growing number of MAPs reveals a more …

Microtubules are one of the major cytoskeletal components of neurons, essential for many
fundamental cellular and developmental processes, such as neuronal migration, polarity …

The ESCRT proteins are an ancient system that buds membranes and severs membrane
necks from their inner face. Three “classical” functions of the ESCRT s have dominated …

Subcortical brain structures are integral to motion, consciousness, emotions and learning.
We identified common genetic variation related to the volumes of the nucleus accumbens …

Neurons are terminally differentiated cells that use their microtubule arrays not for cell
division but rather as architectural elements required for the elaboration of elongated axons …

Tubulin and microtubules are subject to a remarkable number of post-translational
modifications. Understanding the roles these modifications play in determining the functions …

It is widely believed that tau stabilizes microtubules in the axon [1–3] and, hence, that
disease-induced loss of tau from axonal microtubules leads to their destabilization [3–5]. An …

During the past decade enormous advances have been made in our understanding of the
basic molecular machinery that is involved in the development of neuronal polarity. Far from …

Tau is an abundant microtubule-associated protein in neurons. Tau aggregation into
insoluble fibrils is a hallmark of Alzheimer's disease and other types of dementia, yet the …