Musculoskeletal pain conditions are age-related, leading contributors to chronic pain and
pain-related disability, which are expected to rise with the rapid global population aging …

Chronic pain is highly prevalent among older adults where it is associated with significant
suffering, disability, social isolation, and greater costs and burden to health care systems …

Pain is the major symptom of osteoarthritis (OA) and is an important factor in strategies to
manage this disease. However, the current standard of care does not provide satisfactory …

Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms
remain unclear. Here, we investigated an unprecedented role of osteoclast-initiated …

Background Increasing overuse of opioids in the United States may be driven in part by
physician prescribing. However, the extent to which individual physicians vary in opioid …

Importance Persistent pain is highly prevalent, costly, and frequently disabling in later life.
Objective To describe barriers to the management of persistent pain among older adults …

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for their anti-
inflammatory, antipyretic, and analgesic properties. However, their use is often associated …

Objective There is substantial evidence that the use of opioids increases the risk of adverse
outcomes such as delirium, but whether this risk differs between the various opioids remains …

Background Curcumin has been shown to have chondroprotective potential in vitro.
However, its effect on disease and symptom modification in osteoarthritis (OA) is largely …

Knee osteoarthritis (KOA) is the most common form of joint degeneration with increasing
prevalence and incidence in recent decades. KOA is a molecular disorder characterized by …