Non-alcoholic fatty liver disease (NAFLD), currently the leading cause of global chronic liver
disease, has emerged as a major public health problem, more efficient therapeutics of which …

Obesity is a worldwide epidemic that predisposes individuals to cardiometabolic
complications, such as type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease …

Adipose tissue regulates numerous physiological processes, and its dysfunction in obese
humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 …

Kinases have emerged as one of the most intensively pursued targets in current
pharmacological research, especially for cancer, due to their critical roles in cellular …

Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of
insulin resistance. The term insulin resistance is very wide and could affect different proteins …

Immune cell infiltration in (white) adipose tissue (AT) during obesity is associated with the
development of insulin resistance. In AT, the main population of leukocytes are …

Peroxisome proliferator–activated receptors (PPARs) regulate energy metabolism and
hence are therapeutic targets in metabolic diseases such as type 2 diabetes and non …

Cancer cell plasticity facilitates the development of therapy resistance and malignant
progression. De-differentiation processes, such as an epithelial-mesenchymal transition …

It has been more than 36 years since peroxisome proliferator-activated receptors (PPARs)
were first recognized as enhancers of peroxisome proliferation. Consequently, many studies …

Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor
superfamily and they are essential regulators of cell differentiation, tissue development, and …