Lamina-associated domains: links with chromosome architecture, heterochromatin, and gene repression
B Van Steensel, AS Belmont - Cell, 2017 - cell.com
In metazoan cell nuclei, hundreds of large chromatin domains are in close contact with the
nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize …
nuclear lamina. Such lamina-associated domains (LADs) are thought to help organize …
Evaluating the clinical validity of gene-disease associations: an evidence-based framework developed by the clinical genome resource
With advances in genomic sequencing technology, the number of reported gene-disease
relationships has rapidly expanded. However, the evidence supporting these claims varies …
relationships has rapidly expanded. However, the evidence supporting these claims varies …
The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3
Many long non-coding RNAs (lncRNAs) affect gene expression, but the mechanisms by
which they act are still largely unknown. One of the best-studied lncRNAs is Xist, which is …
which they act are still largely unknown. One of the best-studied lncRNAs is Xist, which is …
Stem cell differentiation is regulated by extracellular matrix mechanics
Stem cells mechanosense the stiffness of their microenvironment, which impacts
differentiation. Although tissue hydration anti-correlates with stiffness, extracellular matrix …
differentiation. Although tissue hydration anti-correlates with stiffness, extracellular matrix …
[HTML][HTML] LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation
I Solovei, AS Wang, K Thanisch, CS Schmidt, S Krebs… - Cell, 2013 - cell.com
Eukaryotic cells have a layer of heterochromatin at the nuclear periphery. To investigate
mechanisms regulating chromatin distribution, we analyzed heterochromatin organization in …
mechanisms regulating chromatin distribution, we analyzed heterochromatin organization in …
Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation
Y Gruenbaum, R Foisner - Annual review of biochemistry, 2015 - annualreviews.org
Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …
DHCR7: A vital enzyme switch between cholesterol and vitamin D production
The conversion of 7-dehydrocholesterol to cholesterol, the final step of cholesterol synthesis
in the Kandutsch-Russell pathway, is catalyzed by the enzyme 7-dehydrocholesterol …
in the Kandutsch-Russell pathway, is catalyzed by the enzyme 7-dehydrocholesterol …
PML isoform II plays a critical role in nuclear lipid droplet formation
Y Ohsaki, T Kawai, Y Yoshikawa, J Cheng… - Journal of Cell …, 2016 - rupress.org
Lipid droplets (LDs) in the nucleus of hepatocyte-derived cell lines were found to be
associated with premyelocytic leukemia (PML) nuclear bodies (NBs) and type I …
associated with premyelocytic leukemia (PML) nuclear bodies (NBs) and type I …
Genome organization around nuclear speckles drives mRNA splicing efficiency
The nucleus is highly organized, such that factors involved in the transcription and
processing of distinct classes of RNA are confined within specific nuclear bodies,. One …
processing of distinct classes of RNA are confined within specific nuclear bodies,. One …
Novel players in X inactivation: insights into Xist-mediated gene silencing and chromosome conformation
ST Da Rocha, E Heard - Nature structural & molecular biology, 2017 - nature.com
The nuclear long noncoding RNA (lncRNA) Xist ensures X-chromosome inactivation (XCI) in
female placental mammals. Although Xist is one of the most intensively studied lncRNAs, the …
female placental mammals. Although Xist is one of the most intensively studied lncRNAs, the …