Neurons in the spinal dorsal horn process sensory information, which is then transmitted to
several brain regions, including those responsible for pain perception. The dorsal horn …

Trigeminal sensory nerves relay mechanical, thermal, chemical and proprioceptive
information from craniofacial regions. Trigeminal sensory nerves act at the local level to …

The brain receives sensory input from diverse peripheral tissues, including the skin, the
body's largest sensory organ. Using genetically encoded axonal tracers expressed from the …

Neural circuitry of the spinal superficial dorsal horn (SDH)(laminae I and II) and its
relationship to pain and other somatosensory phenomena remain poorly understood. To …

Most, if not all, nociceptor sensory neurons are dependent on nerve growth factor (NGF)
during early embryonic development. A large subpopulation of these sensory neurons loses …

The processing of sensory, including nociceptive, information in spinal dorsal horn is
critically modulated by spinal GABAergic neurones. For example, blockade of spinal GABAA …

Laminae I-III of the spinal dorsal horn contain many inhibitory interneurons that use GABA
and/or glycine as a neurotransmitter. Distinct neurochemical populations can be recognised …

Loss of synaptic inhibition by γ-aminobutyric acid and glycine due to potassium chloride
cotransporter-2 (KCC2) down-regulation in the spinal cord is a critical mechanism of …

Spinally administered muscarinic receptor agonists or acetylcholinesterase inhibitors can
produce effective pain relief. However, the analgesic mechanisms and the site of actions of …

C-fiber nociceptors can be divided into two groups based on growth factor dependency and
isolectin B4 (IB4) binding. IB4-negative nociceptors have been proposed to contribute to …