The pentose phosphate pathway (PPP) is a glucose-oxidizing pathway that runs in parallel
to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide …

Resistance to anticancer therapies includes primary resistance, usually related to lack of
target dependency or presence of additional targets, and secondary resistance, mostly …

Tumor microenvironment (TME) has been reported to exhibit a crucial effect in lung cancer.
Therefore, this study was aimed to investigate the genes associated with TME and develop a …

Immune checkpoint inhibitors (ICIs) have revolutionized the landscape of therapeutic
options for many cancers. These treatments have demonstrated improved efficacy and often …

Background Autophagy is an intracellular degradation system that removes unnecessary or
dysfunctional components and recycles them for other cellular functions. Over the years, a …

The transcription factor nuclear factor erythroid-derived 2-like 2 (NRF2) participates in the
activation of the antioxidant cytoprotective pathway and other important physiological …

The possibility to analyse the tumour genetic material shed in the blood is undoubtedly one
of the main achievements of translational research in the latest years. In the modern clinical …

SMARCA4, also known as transcription activator, is an ATP-dependent catalytic subunit of
SWI/SNF (SWItch/Sucrose NonFermentable) chromatin-remodeling complexes that …

Immune checkpoint inhibitors (ICIs), either alone or combined with chemotherapy, represent
the cornerstone of the treatment of advanced non-small cell lung cancer (NSCLC) without …

Background SMARCA4, the essential ATPase subunit of SWI/SNF chromatin remodeling
complex, regulates transcription through the control of chromatin structure and is …