Multiple signaling pathways in Sertoli cells: recent findings in spermatogenesis

FD Ni, SL Hao, WX Yang - Cell death & disease, 2019 - nature.com
The functions of Sertoli cells in spermatogenesis have attracted much more attention
recently. Normal spermatogenesis depends on Sertoli cells, mainly due to their influence on …

Relevance of fatty acids to sperm maturation and quality

G Collodel, C Castellini, JCY Lee… - Oxidative medicine and …, 2020 - Wiley Online Library
Almost 50% of infertility cases are associated with human male infertility. The sperm
membrane is a key structure influencing sperm morphology and function in normal and …

MitoQ ameliorates testis injury from oxidative attack by repairing mitochondria and promoting the Keap1-Nrf2 pathway

J Zhang, X Bao, M Zhang, Z Zhu, L Zhou… - Toxicology and applied …, 2019 - Elsevier
Mitochondrial dysfunctions induced by oxidative stress could play a pivotal role in the
development of testicular damage and degeneration, leading to impaired fertility in …

What does androgen receptor signaling pathway in sertoli cells during normal spermatogenesis tell us?

JM Wang, ZF Li, WX Yang - Frontiers in Endocrinology, 2022 - frontiersin.org
Androgen receptor signaling pathway is necessary to complete spermatogenesis in testes.
Difference between androgen binding location in Sertoli cell classifies androgen receptor …

Zearalenone Exposure Disrupts Blood–Testis Barrier Integrity through Excessive Ca2+-Mediated Autophagy

J She, N Feng, W Zheng, H Zheng, P Cai, H Zou… - Toxins, 2021 - mdpi.com
Zearalenone (ZEA), a common mycotoxin in grains and animal feeds, has been associated
with male reproductive disorders. However, the potential toxicity mechanism of ZEA is not …

AMPK function in mammalian spermatozoa

D Martin-Hidalgo, A Hurtado de Llera… - International journal of …, 2018 - mdpi.com
AMP-activated protein kinase AMPK regulates cellular energy by controlling metabolism
through the inhibition of anabolic pathways and the simultaneous stimulation of catabolic …

Diet during early life defines testicular lipid content and sperm quality in adulthood

L Crisóstomo, RA Videira, I Jarak… - American Journal …, 2020 - journals.physiology.org
Childhood obesity is a serious concern associated with ill health later in life. Emerging data
suggest that obesity has long-term adverse effects upon male sexual and reproductive …

Oxidative stress-induced hormonal disruption in male reproduction

DE Rotimi, MA Acho, BM Falana, TD Olaolu… - Reproductive …, 2024 - Springer
Research into the impacts of oxidative stress (OS), and hormonal balance on reproductive
potential has increased over the last 40 years possibly due to rising male infertility …

Pharmacological action of quercetin against testicular dysfunction: A mini review

DE Rotimi, TD Olaolu, OS Adeyemi - Journal of Integrative Medicine, 2022 - Elsevier
The testis is an immune-privileged organ susceptible to oxidative stress and inflammation,
two major factors implicated in male infertility. A reduction in the concentration and activities …

Impacts of immunometabolism on male reproduction

L Ye, W Huang, S Liu, S Cai, L Hong, W Xiao… - Frontiers in …, 2021 - frontiersin.org
The physiological process of male reproduction relies on the orchestration of
neuroendocrine, immune, and energy metabolism. Spermatogenesis is controlled by the …