Zinc finger proteins (ZNF) are among the most abundant proteins in eukaryotic genomes. It
contains several zinc finger domains that can selectively bind to certain DNA or RNA and …

Attention deficit hyperactivity disorder (ADHD) is a polygenic neurodevelopmental disorder
that affects 8–12% of children and> 4% of adults. Environmental factors are believed to …

Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric
disorder of unknown etiology. We performed a whole-genome copy number variation (CNV) …

In recent years, there have been huge advances in the use of genetically modified mice to
study pathophysiological mechanisms involved in schizophrenia. This has allowed rapid …

Animal models are extremely useful tools in defining pathogenesis and treatment of human
disease. Creating adequate animal models of complex neuropsychiatric disorders such as …

Calcineurin (CN), a calcium-and calmodulin-dependent protein phosphatase, plays a
significant role in the central nervous system. Previously, we reported that forebrain-specific …

Dopamine depletion is involved in the pathophysiology of Parkinson's disease, whereas
hyperdopaminergia may play a fundamental role in generating endophenotypes associated …

High levels of impulsive behaviours are a clinically significant symptom in a range of
psychiatric disorders, such as attention deficit hyperactivity disorder, bipolar disorder …

The majority of neurotransmitter systems shows variations in state-dependent cell firing rates
that are mechanistically linked to variations in extracellular levels, or tone, of their respective …

Modulation of fast neurotransmission by monoamines is critically involved in numerous
physiological functions and pathological conditions. Plasma membrane monoamine …