Cystic fibrosis (CF) is a multi-organ genetic disease caused by loss of function of CFTR, a
cAMP-regulated chloride channel expressed in epithelial cells. In airway epithelia, CFTR …

The TMEM16A Ca 2+-gated Cl− channel is involved in a variety of vital physiological
functions and may be targeted pharmacologically for therapeutic benefit in diseases such as …

Background and Purpose Pharmacological inhibitors of TMEM16A (ANO1), a Ca2+‐
activated Cl− channel, are important tools of research and possible therapeutic agents …

Abstract Background and Aims Genome‐wide association studies (GWAS) have identified
several risk loci for gallstone disease. As with most polygenic traits, it is likely that many …

TMEM16A plays critical roles in physiological process and may serve as drug targets for
diverse diseases. Recently, TMEM16A has started to be regarded as potential primary lung …

Cyclic nucleotide elevation in intestinal epithelial cells is the key pathology causing
intestinal fluid loss in secretory diarrheas such as cholera. Current secretory diarrhea …

Chloride transport across cell membranes is broadly involved in epithelial fluid transport, cell
volume and pH regulation, muscle contraction, membrane excitability, and organellar …

Nephrolithiasis is a common and recurrent disease affecting 9% of the US population.
Hyperoxaluria is major risk factor for calcium oxalate kidney stones, which constitute two …

The concept that increasing airway hydration leads to improvements in mucus clearance
and lung function in cystic fibrosis has been clinically validated with osmotic agents such as …

SLC26A6 (also known as putative anion transporter 1 [PAT1]) is a Cl–/HCO 3–exchanger
expressed at the luminal membrane of enterocytes where it facilitates intestinal Cl–and fluid …