The misfolding of the cellular prion protein (PrP C) causes fatal neurodegenerative
diseases. Yet PrP C is highly conserved in mammals, suggesting that it exerts beneficial …

The prion glycoprotein (PrPC) is mostly located at the cell surface, tethered to the plasma
membrane through a glycosyl-phosphatydil inositol (GPI) anchor. Misfolding of PrPC is …

Amyloid-beta (Aβ) oligomers are thought to trigger Alzheimer's disease pathophysiology.
Cellular prion protein (PrPC) selectively binds oligomeric Aβ and can mediate Alzheimer's …

The design of functionalized polymers that can elicit specific biological responses and the
development of methods to fabricate new devices that incorporate biological cues are of …

Alzheimer disease (AD) is the most prevalent cause of dementia. Amyloid-β (Aβ) oligomers
are potent synaptotoxins thought to mediate AD-related phenotypes. Cellular prion protein …

Cytoskeleton modifications are required for neuronal stem cells to acquire neuronal
polarization. Little is known, however, about mechanisms that orchestrate cytoskeleton …

Fyn is a non-receptor tyrosine kinase belonging to the Src family of kinases (SFKs) which
has been implicated in several integral functions throughout the central nervous system …

The accumulation of amyloid-β protein (Aβ) is an early event associated with synaptic and
mitochondrial damage in Alzheimer's disease (AD). Recent studies have implicated the …

The interaction of prion protein (PrP) and α-synuclein (αSyn) oligomers causes synaptic
impairment that might trigger Parkinson's disease and other synucleinopathies. Here, we …

PrP C is highly expressed in both the central and peripheral nervous systems from early
stages of development and in adulthood. Its major conformational change and conversion …