There is an urgent need for new antibiotics against Gram-negative pathogens that are
resistant to carbapenem and third-generation cephalosporins, against which antibiotics of …

The growing emergence of multidrug resistance in bacterial pathogens is an immediate
threat to human health worldwide. Unfortunately, there has not been a matching increase in …

Mitochondria, chloroplasts and Gram-negative bacteria are encased in a double layer of
membranes. The outer membrane contains proteins with a β-barrel structure,. β-Barrels are …

The rising threat of multidrug‐resistant Gram‐negative bacteria is exacerbated by the
scarcity of new antibiotics in the development pipeline. Permeability through the outer …

The folding and insertion of integral β-barrel membrane proteins into the outer membrane of
Gram-negative bacteria is required for viability and bacterial pathogenesis. Unfortunately …

Gram-negative bacteria inhabit a broad range of ecological niches. For Escherichia coli, this
includes river water as well as humans and animals, where it can be both a commensal and …

Outer membrane protein (OMP) biogenesis is an essential process for maintaining the
bacterial cell envelope and involves the β-barrel assembly machinery (BAM) for OMP …

Science occupies an ambiguous space in contemporary society. Scientific research is
championed in relation to tackling environmental issues and diseases such as cancer and …

Numerous high‐value proteins are secreted into the Escherichia coli periplasm by the
General Secretory (Sec) pathway, but Sec‐based production chassis cannot handle many …

The Escherichia coli lac operon promoter is widely used as a tool to control recombinant
protein production in bacteria. Here, we give a brief review of how it functions, how it is …