Peroxisome proliferator‐activated receptor‐γ coactivator (PGC)‐1α is a transcriptional
coactivator described as a master regulator of mitochondrial biogenesis and function …

Abstract Type 2 diabetes (T2D) is a widely prevalent disease with substantial economic and
social impact for which multiple conventional and novel pharmacotherapies are currently …

Background Metabolic disorders such as obesity, insulin resistance and type 2 diabetes
mellitus (DM2) are all linked to diabetic cardiomyopathy that lead to heart failure …

In this review we examine the effects of both over-and under-production of heme oxygenase-
1 (HO-1) and HO activity on a broad spectrum of biological systems and on vascular …

As a serious cardiovascular complication, diabetic cardiomyopathy (DCM) refers to diabetes‐
related changes in myocardial structure and function, which is obviously different from those …

The beneficial effects of pomegranate are due to the ellagitannins and anthocyanins
content, which are protective toward a wide variety of diseases including inflammatory …

Inflammation plays a crucial role in the initiation and development of a wide range of
systemic illnesses. Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid (AA) …

Background/objectives Obesity is a risk factor in the development of type 2 diabetes mellitus
(DM2), which is associated with increased morbidity and mortality, predominantly as a result …

Obesity-mediated metabolic syndrome remains the leading cause of death worldwide.
Among many potential targets for pharmacological intervention, a promising strategy …

There are substantial shortcomings in the drugs currently available for treatment of type 2
diabetes mellitus. The global diabetic crisis has not abated despite the introduction of new …