IDH mutation in glioma: molecular mechanisms and potential therapeutic targets
Isocitrate dehydrogenase (IDH) enzymes catalyse the oxidative decarboxylation of isocitrate
and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances …
and therefore play key roles in the Krebs cycle and cellular homoeostasis. Major advances …
[HTML][HTML] Stem cell programs in cancer initiation, progression, and therapy resistance
Over the past few decades, substantial evidence has convincingly revealed the existence of
cancer stem cells (CSCs) as a minor subpopulation in cancers, contributing to an aberrantly …
cancer stem cells (CSCs) as a minor subpopulation in cancers, contributing to an aberrantly …
Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function
G Notarangelo, JB Spinelli, EM Perez, GJ Baker… - Science, 2022 - science.org
Gain-of-function mutations in isocitrate dehydrogenase (IDH) in human cancers result in the
production of d-2-hydroxyglutarate (d-2HG), an oncometabolite that promotes tumorigenesis …
production of d-2-hydroxyglutarate (d-2HG), an oncometabolite that promotes tumorigenesis …
Mitochondrial DNA variation and cancer
PK Kopinski, LN Singh, S Zhang, MT Lott… - Nature Reviews …, 2021 - nature.com
Variation in the mitochondrial DNA (mtDNA) sequence is common in certain tumours. Two
classes of cancer mtDNA variants can be identified: de novo mutations that act as 'inducers' …
classes of cancer mtDNA variants can be identified: de novo mutations that act as 'inducers' …
Mitochondrial metabolism and cancer
Glycolysis has long been considered as the major metabolic process for energy production
and anabolic growth in cancer cells. Although such a view has been instrumental for the …
and anabolic growth in cancer cells. Although such a view has been instrumental for the …
Hypoxia-modified cancer cell metabolism
W Al Tameemi, TP Dale, RMK Al-Jumaily… - Frontiers in cell and …, 2019 - frontiersin.org
While oxygen is critical to the continued existence of complex organisms, extreme levels of
oxygen within a system, known as hypoxia (low levels of oxygen) and hyperoxia (excessive …
oxygen within a system, known as hypoxia (low levels of oxygen) and hyperoxia (excessive …
Targeting metabolism for cancer therapy
A Luengo, DY Gui, MG Vander Heiden - Cell chemical biology, 2017 - cell.com
Metabolic reprogramming contributes to tumor development and introduces metabolic
liabilities that can be exploited to treat cancer. Chemotherapies targeting metabolism have …
liabilities that can be exploited to treat cancer. Chemotherapies targeting metabolism have …
Metabolic reprogramming and epigenetic modifications on the path to cancer
L Sun, H Zhang, P Gao - Protein & cell, 2022 - academic.oup.com
Metabolic rewiring and epigenetic remodeling, which are closely linked and reciprocally
regulate each other, are among the well-known cancer hallmarks. Recent evidence …
regulate each other, are among the well-known cancer hallmarks. Recent evidence …
Isocitrate dehydrogenase (IDH) mutant gliomas: a Society for Neuro-Oncology (SNO) consensus review on diagnosis, management, and future directions
JJ Miller, LN Gonzalez Castro, S McBrayer… - Neuro …, 2023 - academic.oup.com
Isocitrate dehydrogenase (IDH) mutant gliomas are the most common adult, malignant
primary brain tumors diagnosed in patients younger than 50, constituting an important cause …
primary brain tumors diagnosed in patients younger than 50, constituting an important cause …
Mitochondria and cancer
S Vyas, E Zaganjor, MC Haigis - Cell, 2016 - cell.com
Mitochondria are bioenergetic, biosynthetic, and signaling organelles that are integral in
stress sensing to allow for cellular adaptation to the environment. Therefore, it is not …
stress sensing to allow for cellular adaptation to the environment. Therefore, it is not …