Gut microbiota encompasses a wide variety of commensal microorganisms consisting of
trillions of bacteria, fungi, and viruses. This microbial population coexists in symbiosis with …

Gut microbiota dysbiosis has been repeatedly observed in obesity and type 2 diabetes
mellitus, two metabolic diseases strongly intertwined with non-alcoholic fatty liver disease …

Bile acids are soluble derivatives of cholesterol produced in the liver that subsequently
undergo bacterial transformation yielding a diverse array of metabolites. The bulk of bile …

Abstract Background and Aims The risk factors of cholelithiasis have not been clearly
identified, especially for total cholesterol. Here, we try to identify these causal risk factors …

The largest surface of the human body exposed to the external environment is the gut. At this
level, the intestinal barrier includes luminal microbes, the mucin layer, gastrointestinal …

The intestine plays an important role in nutrient digestion and absorption, microbe defense,
and hormone secretion. Although major cell types have been identified in the mouse …

Of all the novel glucoregulatory molecules discovered in the past 20 years, bile acids (BAs)
are notable for the fact that they were hiding in plain sight. BAs were well known for their …

Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

Bile acids (BAs) are a group of amphiphilic molecules consisting of a rigid steroid core
attached to a hydroxyl group with a varying number, position, and orientation, and a …

The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing worldwide and
parallels comorbidities such as obesity, metabolic syndrome, dyslipidemia, and diabetes …