Broadening the scope of dyslipidemia therapy by targeting APOC3 (apolipoprotein C3) and ANGPTL3 (angiopoietin-like protein 3)
HN Ginsberg, IJ Goldberg - Arteriosclerosis, thrombosis, and …, 2023 - Am Heart Assoc
The positive relationship between increased levels of circulating triglycerides and
cardiovascular events has been observed for decades. Driven by genetic cohort studies …
cardiovascular events has been observed for decades. Driven by genetic cohort studies …
Metabolic origins and clinical significance of LDL heterogeneity
KK Berneis, RM Krauss - Journal of lipid research, 2002 - ASBMB
LDLs in humans comprise multiple distinct subspecies that differ in their metabolic behavior
and pathologic roles. Metabolic turnover studies suggest that this heterogeneity results from …
and pathologic roles. Metabolic turnover studies suggest that this heterogeneity results from …
Targeting APOC3 in the familial chylomicronemia syndrome
D Gaudet, D Brisson, K Tremblay… - … England Journal of …, 2014 - Mass Medical Soc
The familial chylomicronemia syndrome is a genetic disorder characterized by severe
hypertriglyceridemia and recurrent pancreatitis due to a deficiency in lipoprotein lipase …
hypertriglyceridemia and recurrent pancreatitis due to a deficiency in lipoprotein lipase …
A Null Mutation in Human APOC3 Confers a Favorable Plasma Lipid Profile and Apparent Cardioprotection
TI Pollin, CM Damcott, H Shen, SH Ott, J Shelton… - Science, 2008 - science.org
Apolipoprotein C-III (apoC-III) inhibits triglyceride hydrolysis and has been implicated in
coronary artery disease. Through a genome-wide association study, we have found that …
coronary artery disease. Through a genome-wide association study, we have found that …
Hepatocyte nuclear factor 4α (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis
GP Hayhurst, YH Lee, G Lambert, JM Ward… - … and cellular biology, 2001 - Taylor & Francis
The numerous functions of the liver are controlled primarily at the transcriptional level by the
concerted actions of a limited number of hepatocyte-enriched transcription factors …
concerted actions of a limited number of hepatocyte-enriched transcription factors …
Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
The three types of peroxisome proliferator-activated receptors (PPAR), termed alpha, delta
(or beta), and gamma, belong to the nuclear receptor superfamily. Although peroxisome …
(or beta), and gamma, belong to the nuclear receptor superfamily. Although peroxisome …
ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors
PLSM Gordts, R Nock, NH Son… - The Journal of …, 2016 - Am Soc Clin Investig
Hypertriglyceridemia is an independent risk factor for cardiovascular disease, and plasma
triglycerides (TGs) correlate strongly with plasma apolipoprotein C-III (ApoC-III) levels …
triglycerides (TGs) correlate strongly with plasma apolipoprotein C-III (ApoC-III) levels …
An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing
LA Pennacchio, M Olivier, JA Hubacek, JC Cohen… - Science, 2001 - science.org
Comparison of genomic DNA sequences from human and mouse revealed a new
apolipoprotein (APO) gene (APOAV) located proximal to the well-characterized …
apolipoprotein (APO) gene (APOAV) located proximal to the well-characterized …
A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism
A Rigotti, BL Trigatti, M Penman… - Proceedings of the …, 1997 - National Acad Sciences
Plasma high density lipoprotein (HDL), which protects against atherosclerosis, is thought to
remove cholesterol from peripheral tissues and to deliver cholesteryl esters via a selective …
remove cholesterol from peripheral tissues and to deliver cholesteryl esters via a selective …
Role of ApoCs in lipoprotein metabolism: functional differences between ApoC1, ApoC2, and ApoC3
The human apoCs (ie, apoC1, apoC2, and apoC3) are often portrayed as members of 1
consistent protein family because of their similar distributions among lipoprotein classes …
consistent protein family because of their similar distributions among lipoprotein classes …