The genetics of multiple sclerosis: from 0 to 200 in 50 years

SE Baranzini, JR Oksenberg - Trends in genetics, 2017 - cell.com
Multiple sclerosis (MS) is a common autoimmune disease that targets myelin in the central
nervous system (CNS). Multiple genome-wide association studies (GWAS) over the past 10 …

The genetics of multiple sclerosis: an up‐to‐date review

PA Gourraud, HF Harbo, SL Hauser… - Immunological …, 2012 - Wiley Online Library
Multiple sclerosis (MS) is a prevalent inflammatory disease of the central nervous system
that often leads to disability in young adults. Treatment options are limited and often only …

Axonal transection in the lesions of multiple sclerosis

BD Trapp, J Peterson, RM Ransohoff… - … England Journal of …, 1998 - Mass Medical Soc
Background Multiple sclerosis is an inflammatory demyelinating disease of the central
nervous system and is the most common cause of neurologic disability in young adults …

Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination

C Lucchinetti, W Brück, J Parisi… - Annals of Neurology …, 2000 - Wiley Online Library
Multiple sclerosis (MS) is a disease with profound heterogeneity in clinical course,
neuroradiological appearance of the lesions, involvement of susceptibility gene loci, and …

Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis

C Lock, G Hermans, R Pedotti, A Brendolan… - Nature medicine, 2002 - nature.com
Microarray analysis of multiple sclerosis (MS) lesions obtained at autopsy revealed
increased transcripts of genes encoding inflammatory cytokines, particularly interleukin-6 …

Risk alleles for multiple sclerosis identified by a genomewide study

International Multiple Sclerosis Genetics … - New England Journal …, 2007 - Mass Medical Soc
Background Multiple sclerosis has a clinically significant heritable component. We
conducted a genomewide association study to identify alleles associated with the risk of …

The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease

D Chabas, SE Baranzini, D Mitchell, CCA Bernard… - Science, 2001 - science.org
Multiple sclerosis is a demyelinating disease, characterized by inflammation in the brain and
spinal cord, possibly due to autoimmunity. Large-scale sequencing of cDNA libraries …

Genetics of multiple sclerosis

DA Dyment, GC Ebers, AD Sadovnick - The Lancet Neurology, 2004 - thelancet.com
Multiple sclerosis (MS) is probably aetiologically heterogeneous. Systematic genetic
epidemiological and molecular genetic studies have provided important insights. Both …

Multiple sclerosis: a two-stage disease

L Steinman - Nature immunology, 2001 - nature.com
Multiple sclerosis: a two-stage disease | Nature Immunology Skip to main content Thank you
for visiting nature.com. You are using a browser version with limited support for CSS. To obtain …

A Pathogenic Role for Myelin-Specific Cd8+ T Cells in a Model for Multiple Sclerosis

ES Huseby, D Liggitt, T Brabb, B Schnabel… - The Journal of …, 2001 - rupress.org
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS)
characterized by plaques of infiltrating CD4+ and CD8+ T cells. Studies of MS and …