Mitochondria are recognized as one of the most important targets for new drug design in
cancer, cardiovascular, and neurological diseases. Currently, the most effective way to …

Mitochondria are indispensable for energy metabolism, apoptosis regulation, and cell
signaling. Mitochondria in malignant cells differ structurally and functionally from those in …

Mitochondria are a major target in hypoxic/ischemic injury. Mitochondrial impairment
increases with age leading to dysregulation of molecular pathways linked to mitochondria …

The free radical theory of aging proposes that reactive oxygen species (ROS)-induced
accumulation of damage to cellular macromolecules is a primary driving force of aging and a …

Cyclodextrin (CD) has special spatial structure and well biological safety, so it has been
widely used for constructing CD-based nanoplatforms. Through functionalization …

Mitochondrial targeting is a promising approach for solving current issues in clinical
application of chemotherapy and diagnosis of several disorders. Here, we discuss direct …

Parkinson's disease is a progressive neurodegenerative disease in the elderly, and no cure
or disease-modifying therapies exist. Several lines of evidence suggest that mitochondrial …

Mitochondria are essential cellular organelles, controlling multiple signalling pathways
critical for cell survival and cell death. Increasing evidence suggests that mitochondrial …

Mitochondrial function and specifically its implication in cellular redox/oxidative balance is
fundamental in controlling the life and death of cells, and has been implicated in a wide …

The mitochondria of various tissues from mice, naked mole rats (NMRs), and bats possess
two mechanistically similar systems to prevent the generation of mitochondrial reactive …