Lung cancer in patients who have never smoked—An emerging disease

J LoPiccolo, A Gusev, DC Christiani… - Nature Reviews Clinical …, 2024 - nature.com
Lung cancer is the most common cause of cancer-related deaths globally. Although smoking-
related lung cancers continue to account for the majority of diagnoses, smoking rates have …

Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer

J Byun, Y Han, Y Li, J Xia, E Long, J Choi, X Xiao… - Nature …, 2022 - nature.com
To identify new susceptibility loci to lung cancer among diverse populations, we performed
cross-ancestry genome-wide association studies in European, East Asian and African …

[HTML][HTML] Lung cancer risk in never-smokers: An overview of environmental and genetic factors

ES Cheng, M Weber, J Steinberg… - Chinese Journal of …, 2021 - ncbi.nlm.nih.gov
Lung cancer is the leading cause of cancer-related mortality globally, accounting for 1.8
million deaths in 2020. While the vast majority are caused by tobacco smoking, 15%− 25 …

[HTML][HTML] Screening for lung cancer in individuals who never smoked: an international association for the study of lung cancer early detection and screening committee …

A Kerpel-Fronius, M Tammemägi, M Cavic… - Journal of Thoracic …, 2022 - Elsevier
Screening with low-dose computed tomography of high-risk individuals with a smoking
history reduces lung cancer mortality. Current screening guidelines and eligibility criteria …

Functional studies of lung cancer GWAS beyond association

E Long, H Patel, J Byun, CI Amos… - Human molecular …, 2022 - academic.oup.com
Fourteen years after the first genome-wide association study (GWAS) of lung cancer was
published, approximately 45 genomic loci have now been significantly associated with lung …

[HTML][HTML] A large-scale genome-wide gene-gene interaction study of lung cancer susceptibility in Europeans with a trans-ethnic validation in Asians

R Zhang, S Shen, Y Wei, Y Zhu, Y Li, J Chen… - Journal of Thoracic …, 2022 - Elsevier
Introduction Although genome-wide association studies have been conducted to investigate
genetic variation of lung tumorigenesis, little is known about gene-gene (G× G) interactions …

[HTML][HTML] Inherited lung cancer: a review

VTL de Alencar, MN Formiga… - Ecancermedicalscience, 2020 - ncbi.nlm.nih.gov
Lung cancer is the most common cancer worldwide and has high rates of mortality. The
major risk factor associated with this disease is tobacco smoke, but approximately 10 …

Geographic differences in lung cancer: focus on carcinogens, genetic predisposition, and molecular epidemiology

JC Laguna, M García-Pardo, J Alessi… - Therapeutic …, 2024 - journals.sagepub.com
Lung cancer poses a global health challenge and stands as the leading cause of cancer-
related deaths worldwide. However, its incidence, mortality, and characteristics are not …

New insights into the biology and development of lung cancer in never smokers—implications for early detection and treatment

P Wang, S Sun, S Lam, WW Lockwood - Journal of Translational Medicine, 2023 - Springer
Lung cancer is the leading cause of cancer deaths worldwide. Despite never smokers
comprising between 10 and 25% of all cases, lung cancer in never smokers (LCNS) is …

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

J Shi, K Shiraishi, J Choi, K Matsuo, TY Chen… - Nature …, 2023 - nature.com
Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain
only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage …