The blood–retina barrier in health and disease

F O'Leary, M Campbell - The FEBS journal, 2023 - Wiley Online Library
The blood–retina barrier (BRB) is the term used to define the properties of the retinal
capillaries and the retinal pigment epithelium (RPE), which separate the systemic circulation …

Prevention of microvascular complications of diabetes

W Crasto, V Patel, MJ Davies… - … and Metabolism Clinics, 2021 - endo.theclinics.com
Global prevalence estimates from 2019 suggest that the number of people diagnosed with
diabetes was 463 million and is projected to increase to 700 million by the year 2045. 1 The …

The innate immune system in diabetic retinopathy

WW Pan, F Lin, PE Fort - Progress in retinal and eye research, 2021 - Elsevier
The prevalence of diabetes has been rising steadily in the past half-century, along with the
burden of its associated complications, including diabetic retinopathy (DR). DR is currently …

[HTML][HTML] Diabetic retinopathy for the non-ophthalmologist

THM Fung, B Patel, EG Wilmot, WMK Amoaku - Clinical Medicine, 2022 - Elsevier
Diabetic retinopathy is a microangiopathy resulting from the chronic effects of diabetes
mellitus. Healthcare professionals often work in isolation to deliver highly specialised care …

The role of intravitreal corticosteroids in the treatment of DME: predictive OCT biomarkers

MR Munk, GM Somfai, MD de Smet, G Donati… - International journal of …, 2022 - mdpi.com
This work aims to summarize predictive biomarkers to guide treatment choice in DME.
Intravitreal anti-VEGF is considered the gold standard treatment for centers involving DME …

[HTML][HTML] TXNIP positively regulates the autophagy and apoptosis in the rat müller cell of diabetic retinopathy

H Ao, H Li, X Zhao, B Liu, L Lu - Life sciences, 2021 - Elsevier
Aims Diabetic retinopathy (DR) can cause vision loss in patients with diabetes. The present
study evaluated the expression of thioredoxin interacting protein (TXNIP) and investigated …

Oxidative stress, inflammatory, angiogenic, and apoptotic molecules in proliferative diabetic retinopathy and diabetic macular edema patients

I Andrés-Blasco, A Gallego-Martínez… - International journal of …, 2023 - mdpi.com
The aim of this study is to evaluate molecules involved in oxidative stress (OS),
inflammation, angiogenesis, and apoptosis, and discern which of these are more likely to be …

In-depth transcriptomic analysis of human retina reveals molecular mechanisms underlying diabetic retinopathy

K Becker, H Klein, E Simon, C Viollet, C Haslinger… - Scientific reports, 2021 - nature.com
Diabetic Retinopathy (DR) is among the major global causes for vision loss. With the rise in
diabetes prevalence, an increase in DR incidence is expected. Current understanding of …

Molecular investigation of candidate genes for pyroptosis-induced inflammation in diabetic retinopathy

N Wang, L Ding, D Liu, Q Zhang, G Zheng… - Frontiers in …, 2022 - frontiersin.org
Background Diabetic retinopathy is a diabetic microvascular complication. Pyroptosis, as a
way of inflammatory death, plays an important role in the occurrence and development of …

LRG1 as a novel therapeutic target in eye disease

G De Rossi, ME Da Vitoria Lobo, J Greenwood… - Eye, 2022 - nature.com
Retinal and choroidal diseases are major causes of blindness and visual impairment in the
developed world and on the rise due to an ageing population and diabetes epidemic …