Pulmonary hypertension encompasses a range of conditions directly or indirectly leading to
elevated pressures within the pulmonary arteries. Five main groups of pulmonary …

The pulmonary circulation is a low-resistance, low-pressure, and high-compliance system
that allows the lungs to receive the entire cardiac output. Pulmonary arterial pressure is a …

Emerging studies have reported the mechanosensitive Piezo1 (piezo type
mechanosensitive ion channel component 1) plays essential roles in regulating the vascular …

Piezo is a mechanosensitive cation channel responsible for stretch-mediated Ca2+ and Na+
influx in multiple types of cells. Little is known about the functional role of Piezo1 in the lung …

Idiopathic pulmonary arterial hypertension (PAH) is a fatal and progressive disease.
Sustained vasoconstriction due to pulmonary arterial smooth muscle cell (PASMC) …

Background and Purpose Pulmonary arterial hypertension (PAH) is a pulmonary
vasculature obstructive disease that leads to right heart failure and death. Maresin 1 is an …

Cardiac, skeletal, and smooth muscle cells shared the common feature of contraction in
response to different stimuli. Agonist-induced muscle's contraction is triggered by a cytosolic …

The Orai1 channel is regulated by stromal interaction molecules STIM1 and STIM2 within
endoplasmic reticulum (ER)-plasma membrane (PM) contact sites. Ca2+ signals generated …

Concentric pulmonary vascular wall thickening due partially to increased pulmonary artery
(PA) smooth muscle cell (PASMC) proliferation contributes to elevating pulmonary vascular …

The stromal interaction molecules (STIMs) are the sarcoplasmic reticulum (SR) Ca 2+
sensors that trigger store-operated Ca 2+ entry (SOCE) in a variety of cell types. While …