Two-pore channels TPC1 and TPC2 are ubiquitously expressed pathophysiologically
relevant proteins that reside on endolysosomal vesicles. Here, we review the …

The endomembrane system consists of organellar membranes in the biosynthetic pathway
[endoplasmic reticulum (ER), Golgi apparatus, and secretory vesicles] as well as those in the …

The lysosomal cation channel TMEM175 is a Parkinson's disease-related protein and a
promising drug target. Unlike whole-cell automated patch-clamp (APC), lysosomal patch …

NAADP (nicotinic acid adenine dinucleotide phosphate) is a second messenger, releasing
Ca 2+ from acidic calcium stores such as endosomes and lysosomes. PI (3, 5) P 2 …

Ascorbate (Asc) is a major redox buffer of plant cells, whose antioxidant activity depends on
the ratio with its one‐electron oxidation product monodehydroascorbate (MDHA). The …

Ion channels are key signaling proteins found throughout the body; they are critical in many,
wide-ranging physiological processes, from gene expression, sensory perception and …

Human endo-lysosomes possess a class of proteins called TPC channels on their
membrane, which are essential for proper cell functioning. This protein family can be …

The plant vacuole plays a fundamental role in cell homeostasis. The successful application
of patch-clamp technique on isolated vacuoles allows the determination of the functional …

Актуальность темы. Наряду с неоспоримыми достоинствами методов изучения
качественных показателей трансмемебранного транспорта на модельных системах …