In the healthy endometrium, progesterone and estrogen signaling coordinate in a tightly
regulated, dynamic interplay to drive a normal menstrual cycle and promote an embryo …

Implantation and the establishment of pregnancy are critical for the propagation of the
species, but yet remain the limiting steps in human and primate reproduction. Successful …

Successful embryo implantation requires a receptive endometrium. Poor uterine receptivity
can account for implantation failure in women who experience recurrent pregnancy loss or …

Programmed cellular responses to cycling ovarian-derived steroid hormones are central to
normal endometrial function. Abnormalities therein, as in the estrogen-dependent …

Several factors are important for implantation and subsequent placentation in the
endometrium, including immunity, angiogenesis, extracellular matrix, glucose metabolism …

BACKGROUND Endometrium is a vital multicellular tissue for progression of pregnancy.
Forkhead box O1 (FoxO1) transcription factor plays an important role in the endometrium as …

Progesterone's ability to maintain pregnancy in eutherian mammals highlighted this steroid
as the “hormone of pregnancy”. It was the unique “pro-gestational” bioactivity of …

Progesterone acts through the progesterone receptor to direct physiological adaption of the
uterus in preparation and completion of pregnancy. Genome-wide transcriptome and …

Endometriosis is the most common cause of infertility. Endometrial receptivity has been
suggested to contribute to infertility and poor reproductive outcomes in affected women …

Decidualization is an intricate biological process where extensive morphological, functional,
and genetic changes take place in endometrial stromal cells to support the development of …