Cellular rewiring in lethal prostate cancer: the architect of drug resistance
M Carceles-Cordon, WK Kelly, L Gomella… - Nature reviews …, 2020 - nature.com
Over the past 5 years, the advent of combination therapeutic strategies has substantially
reshaped the clinical management of patients with advanced prostate cancer. However …
reshaped the clinical management of patients with advanced prostate cancer. However …
At the Bench: Pre-clinical evidence for multiple functions of CXCR4 in cancer
Signaling through chemokine receptor, CXC chemokine receptor type 4 (CXCR4) regulates
essential processes in normal physiology, including embryogenesis, tissue repair …
essential processes in normal physiology, including embryogenesis, tissue repair …
miR-331-3p regulates ERBB-2 expression and androgen receptor signaling in prostate cancer
MicroRNAs (miRNAs) are short, non-coding RNAs that regulate gene expression and are
aberrantly expressed in human cancer. The ERBB-2 tyrosine kinase receptor is frequently …
aberrantly expressed in human cancer. The ERBB-2 tyrosine kinase receptor is frequently …
Disruption of androgen and estrogen receptor activity in prostate cancer by a novel dietary diterpene carnosol: implications for chemoprevention
JJ Johnson, DN Syed, Y Suh, CR Heren… - Cancer prevention …, 2010 - AACR
Emerging data are suggesting that estrogens, in addition to androgens, may also be
contributing to the development of prostate cancer (PCa). In view of this notion, agents that …
contributing to the development of prostate cancer (PCa). In view of this notion, agents that …
Stem cells as target for prostate cancer therapy: opportunities and challenges
C Escudero-Lourdes, I Alvarado-Morales… - Stem cell reviews and …, 2022 - Springer
Cancer stem cells (CSCs) and cells in a cancer stem cell-like (CSCL) state have proven to
be responsible for tumor initiation, growth, and relapse in Prostate Cancer (PCa) and other …
be responsible for tumor initiation, growth, and relapse in Prostate Cancer (PCa) and other …
KPT-330, a potent and selective exportin-1 (XPO-1) inhibitor, shows antitumor effects modulating the expression of cyclin D1 and survivin in prostate cancer models
GL Gravina, A Mancini, P Sanita, F Vitale, F Marampon… - BMC cancer, 2015 - Springer
Background and aims Increased expression of Chromosome Region Maintenance (CRM-
1)/exportin-1 (XPO-1) has been correlated with poor prognosis in several aggressive tumors …
1)/exportin-1 (XPO-1) has been correlated with poor prognosis in several aggressive tumors …
CXCR4 pharmacogical inhibition reduces bone and soft tissue metastatic burden by affecting tumor growth and tumorigenic potential in prostate cancer preclinical …
BACKGROUND The majority of prostate cancer (Pca) patient morbidity can be attributed to
bone metastatic events, which poses a significant clinical obstacle. Therefore, a better …
bone metastatic events, which poses a significant clinical obstacle. Therefore, a better …
Dual EGFR/HER2 inhibition sensitizes prostate cancer cells to androgen withdrawal by suppressing ErbB3
L Chen, BA Mooso, MK Jathal, A Madhav… - Clinical Cancer …, 2011 - AACR
Purpose: Patients with recurrent prostate cancer are commonly treated with androgen
withdrawal therapy (AWT); however, almost all patients eventually progress to castration …
withdrawal therapy (AWT); however, almost all patients eventually progress to castration …
Significant systemic therapeutic effects of high-LET immunoradiation by 212Pb-trastuzumab against prostatic tumors of androgen-independent human prostate cancer …
Z Tan, P Chen, N Schneider… - International …, 2012 - spandidos-publications.com
The purpose of this study was to determine therapeutic effects and systemic toxicity of 212Pb-
trastuzumab in an orthotopic model of human prostate cancer cells in nude mice. TCMC …
trastuzumab in an orthotopic model of human prostate cancer cells in nude mice. TCMC …
Hormonal therapy promotes hormone-resistant phenotype by increasing DNMT activity and expression in prostate cancer models
GL Gravina, F Marampon, M Piccolella, M Motta… - …, 2011 - academic.oup.com
We hypothesized that hormonal therapy favors the development of the hormone-resistant
phenotype through epigenetic mechanisms. Human prostate cancer tissues and in vitro and …
phenotype through epigenetic mechanisms. Human prostate cancer tissues and in vitro and …