Medicinal plants for the treatment of local tissue damage induced by snake venoms: an overview from traditional use to pharmacological evidence

J Félix-Silva, AA Silva-Junior… - Evidence‐Based …, 2017 - Wiley Online Library
Snakebites are a serious problem in public health due to their high morbimortality. Most of
snake venoms produce intense local tissue damage, which could lead to temporary or …

Plant-derived toxin inhibitors as potential candidates to complement antivenom treatment in snakebite envenomations

AAX Adrião, AO Dos Santos, EJSP de Lima… - Frontiers in …, 2022 - frontiersin.org
Snakebite envenomations (SBEs) are a neglected medical condition of global importance
that mainly affect the tropical and subtropical regions. Clinical manifestations include pain …

The synthetic varespladib molecule is a multi-functional inhibitor for PLA2 and PLA2-like ophidic toxins

GHM Salvador, RJ Borges, B Lomonte… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Background The treatment for snakebites is early administration of antivenom, which can be
highly effective in inhibiting the systemic effects of snake venoms, but is less effective in the …

Inhibitory effects of hydroethanolic leaf extracts of Kalanchoe brasiliensis and Kalanchoe pinnata (Crassulaceae) against local effects induced by Bothrops jararaca …

JM Fernandes, J Felix-Silva, LM da Cunha… - PloS one, 2016 - journals.plos.org
The species Kalanchoe brasiliensis and Kalanchoe pinnata, both known popularly as
“Saião,” are used interchangeably in traditional medicine for their antiophidic properties …

[HTML][HTML] The potential of phenolic acids in therapy against snakebites: A review

S de Sousa Ferreira, DP da Silva, M Torres-Rêgo… - Toxicon, 2022 - Elsevier
Ophidism is a serious health problem worldwide and is included in the World Health
Organization's (WHO's) list of Neglected Tropical Diseases. Although snakebite envenoming …

Search for efficient inhibitors of myotoxic activity induced by ophidian phospholipase A2-like proteins using functional, structural and bioinformatics approaches

GHM Salvador, FF Cardoso, AA Gomes… - Scientific Reports, 2019 - nature.com
Ophidian accidents are considered an important neglected tropical disease by the World
Health Organization. Particularly in Latin America, Bothrops snakes are responsible for the …

[HTML][HTML] Ethnomedicinal breakthroughs in snake bite therapy: From folklore to forefront

SS Hussain, D Kingsley - Toxicology Reports, 2024 - Elsevier
Snakebite envenomation is a critical public health issue, especially in tropical regions like
India, resulting in significant morbidity and mortality. This review explores the potential of …

[HTML][HTML] The potential of Brazilian native plant species used in the therapy for snakebites: A literature review

EL Konrath, I Strauch, DD Boeff, MD Arbo - Toxicon, 2022 - Elsevier
Snakebite envenoming is a potentially fatal disease categorized as a neglected public
health issue for not receiving the appropriate attention from national and international health …

Study on the anticoagulant or procoagulant activities of type II phenolic acid derivatives

X Luo, C Du, H Cheng, J Chen, C Lin - Molecules, 2017 - mdpi.com
In this study, three type II phenolic acids (caffeic acid, p-hydroxycinnamic acid, and ferulic
acid) were used to synthesize a total of 18 phenolic acid derivatives. With molecular docking …

Protective Effect of the Plant Extracts of Erythroxylum sp. against Toxic Effects Induced by the Venom of Lachesis muta Snake

E Coriolano de Oliveira, R Alves Soares Cruz… - Molecules, 2016 - mdpi.com
Snake venoms are composed of a complex mixture of active proteins that induce toxic
effects, such as edema, hemorrhage, and death. Lachesis muta has the highest lethality …