Aging is the primary risk factor underlying hypertension and incident cardiovascular disease.
With aging, the vasculature undergoes structural and functional changes characterized by …

The kidneys play a key role in maintaining total body homeostasis. The complexity of this
task is reflected in the unique architecture of the organ. Ureteral obstruction greatly affects …

Aging can be seen as process characterized by accumulation of oxidative stress induced
damage. Oxidative stress derives from different endogenous and exogenous processes, all …

Unilateral ureteral obstruction (UUO) is an experimental rodent model that mimics renal
fibrosis associated with obstructive nephropathy in an accelerated manner. After UUO, the …

All progressive renal diseases are the consequence of a process of destructive fibrosis. This
review will focus on tubulointerstitial fibrosis, the pathophysiology of which will be divided …

Interstitial fibrosis has a major role in the progression of renal diseases. Several animal
models are available for the study of renal fibrosis. The models of aminonucleoside-induced …

Angiotensin (Ang) II, the main peptide of the renin angiotensin system (RAS), is a renal
growth factor, inducing hyperplasia/hypertrophy depending on the cell type. This vasoactive …

Unilateral ureteral obstruction is a popular experimental model of renal injury. However, the
study of the kidney response to urinary tract obstruction is only one of several advantages of …

T he retractile and remodeling phenomena accompanying and, in pathologic situations,
following the healing of an open wound have attracted the interest of physicians and …

Heart failure is a major health problem worldwide. In the United States, it represents the
number one hospital discharge diagnosis among elderly persons each year. It appears most …