Activation of cold-sensing transient receptor potential melastatin subtype 8 antagonizes vasoconstriction and hypertension through attenuating RhoA/Rho kinase …
Environmental cold is a nonmodifiable hypertension risk factor. Transient receptor potential
melastatin subtype 8 (TRPM8) is a cold-sensing cation channel that can be activated by …
melastatin subtype 8 (TRPM8) is a cold-sensing cation channel that can be activated by …
TRPM4 channels couple purinergic receptor mechanoactivation and myogenic tone development in cerebral parenchymal arterioles
Y Li, RL Baylie, MJ Tavares… - Journal of Cerebral …, 2014 - journals.sagepub.com
Cerebral parenchymal arterioles (PAs) have a critical role in assuring appropriate blood flow
and perfusion pressure within the brain. They are unique in contrast to upstream pial …
and perfusion pressure within the brain. They are unique in contrast to upstream pial …
RhoA enhances store-operated Ca2+ entry and intestinal epithelial restitution by interacting with TRPC1 after wounding
HK Chung, N Rathor, SR Wang… - American Journal of …, 2015 - journals.physiology.org
Early mucosal restitution occurs as a consequence of epithelial cell migration to resealing of
superficial wounds after injury. Our previous studies show that canonical transient receptor …
superficial wounds after injury. Our previous studies show that canonical transient receptor …
Rho kinase proteins regulate global miRNA expression in endothelial cells
JM Stiles, V Kurisetty, DC Mitchell… - Cancer Genomics & …, 2013 - cgp.iiarjournals.org
Background: Therapeutic targeting of Rho-Associated, Coiled-Coil Containing Protein
Kinase (ROCK) signaling for tumor cells and tumor endothelium has shown efficacy in pre …
Kinase (ROCK) signaling for tumor cells and tumor endothelium has shown efficacy in pre …
Role of Orai1 and L-type CaV1. 2 channels in Endothelin-1 mediated coronary contraction under ischemia and reperfusion
EM Calderón-Sánchez, J Ávila-Medina… - Cell Calcium, 2020 - Elsevier
Abstract Ischemia and Reperfusion (I/R) injuries are associated with coronary artery
hypercontracture. They are mainly originated by an exacerbated response to agonists …
hypercontracture. They are mainly originated by an exacerbated response to agonists …
Mechanisms of sphingosine‐1‐phosphate‐mediated vasoconstriction of rat afferent arterioles
Abstract Aim Sphingosine‐1‐phosphate (S1P) influences resistance vessel function and is
implicated in renal pathological processes. Previous studies revealed that S1P evoked …
implicated in renal pathological processes. Previous studies revealed that S1P evoked …
Rho kinase inhibitors reduce voltage-dependent Ca2+ channel signaling in aortic and renal microvascular smooth muscle cells
Z Guan, JJ Baty, S Zhang… - American Journal of …, 2019 - journals.physiology.org
Voltage-dependent L-type Ca2+ channels (L-VDCCs) and the RhoA/Rho kinase pathway
are two predominant intracellular signaling pathways that regulate renal microvascular …
are two predominant intracellular signaling pathways that regulate renal microvascular …
Development of Second‐Generation Small‐Molecule RhoA Inhibitors with Enhanced Water Solubility, Tissue Potency, and Significant in vivo Efficacy
RhoA, a member of the Rho GTPases, is involved in a variety of cellular functions and could
be a suitable therapeutic target for the treatment of cardiovascular diseases. However, few …
be a suitable therapeutic target for the treatment of cardiovascular diseases. However, few …
[HTML][HTML] Implicación de los canales de Ca2+ tipo L y RhoA/Rho quinasa en el incremento del tono vascular inducido por la despolarización mantenida: posible papel …
C Porras-González - 2017 - dialnet.unirioja.es
Nuestro grupo está interesado en estudiar los mecanismos implicados en el mantenimiento
del tono vascular en situaciones fisiológicas y fisiopatológicas. Concretamente, nuestro …
del tono vascular en situaciones fisiológicas y fisiopatológicas. Concretamente, nuestro …
Contribution of L-type Ca2+ channel-sarcoplasmic reticulum coupling to depolarization-induced arterial contraction in spontaneously hypertensive rats
C Porras-González, A Castellano, J Ureña - Hypertension Research, 2018 - nature.com
Evidence has shown that vascular smooth muscle cells (VSMCs) of spontaneously
hypertensive rats (SHRs) are depolarized and that the expression of L-type Ca2+ channels …
hypertensive rats (SHRs) are depolarized and that the expression of L-type Ca2+ channels …