Environmental cold is a nonmodifiable hypertension risk factor. Transient receptor potential
melastatin subtype 8 (TRPM8) is a cold-sensing cation channel that can be activated by …

Cerebral parenchymal arterioles (PAs) have a critical role in assuring appropriate blood flow
and perfusion pressure within the brain. They are unique in contrast to upstream pial …

Early mucosal restitution occurs as a consequence of epithelial cell migration to resealing of
superficial wounds after injury. Our previous studies show that canonical transient receptor …

Background: Therapeutic targeting of Rho-Associated, Coiled-Coil Containing Protein
Kinase (ROCK) signaling for tumor cells and tumor endothelium has shown efficacy in pre …

Abstract Ischemia and Reperfusion (I/R) injuries are associated with coronary artery
hypercontracture. They are mainly originated by an exacerbated response to agonists …

Abstract Aim Sphingosine‐1‐phosphate (S1P) influences resistance vessel function and is
implicated in renal pathological processes. Previous studies revealed that S1P evoked …

Voltage-dependent L-type Ca2+ channels (L-VDCCs) and the RhoA/Rho kinase pathway
are two predominant intracellular signaling pathways that regulate renal microvascular …

RhoA, a member of the Rho GTPases, is involved in a variety of cellular functions and could
be a suitable therapeutic target for the treatment of cardiovascular diseases. However, few …

Nuestro grupo está interesado en estudiar los mecanismos implicados en el mantenimiento
del tono vascular en situaciones fisiológicas y fisiopatológicas. Concretamente, nuestro …

Evidence has shown that vascular smooth muscle cells (VSMCs) of spontaneously
hypertensive rats (SHRs) are depolarized and that the expression of L-type Ca2+ channels …