Meningeal immunity and its function in maintenance of the central nervous system in health and disease

K Alves de Lima, J Rustenhoven… - Annual review of …, 2020 - annualreviews.org
Neuroimmunology, albeit a relatively established discipline, has recently sparked numerous
exciting findings on microglia, the resident macrophages of the central nervous system …

Multifaceted interactions between adaptive immunity and the central nervous system

J Kipnis - Science, 2016 - science.org
Neuroimmunologists seek to understand the interactions between the central nervous
system (CNS) and the immune system, both under homeostatic conditions and in diseases …

The resolution of neuroinflammation in neurodegeneration: leukocyte recruitment via the choroid plexus

M Schwartz, K Baruch - The EMBO journal, 2014 - embopress.org
Inflammation is an integral part of the body's physiological repair mechanism, unless it
remains unresolved and becomes pathological, as evident in the progressive nature of …

Inflammation in neurodegenerative disease—a double-edged sword

T Wyss-Coray, L Mucke - Neuron, 2002 - cell.com
Inflammation is a defense reaction against diverse insults, designed to remove noxious
agents and to inhibit their detrimental effects. It consists of a dazzling array of molecular and …

Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury

DJ Donnelly, PG Popovich - Experimental neurology, 2008 - Elsevier
Trauma to the central nervous system (CNS) triggers intraparenchymal inflammation and
activation of systemic immunity with the capacity to exacerbate neuropathology and …

How and why do T cells and their derived cytokines affect the injured and healthy brain?

AJ Filiano, SP Gadani, J Kipnis - Nature Reviews Neuroscience, 2017 - nature.com
The evolution of adaptive immunity provides enhanced defence against specific pathogens,
as well as homeostatic immune surveillance of all tissues. Despite being'immune privileged' …

T cell deficiency leads to cognitive dysfunction: implications for therapeutic vaccination for schizophrenia and other psychiatric conditions

J Kipnis, H Cohen, M Cardon, Y Ziv… - Proceedings of the …, 2004 - National Acad Sciences
The effects of the adaptive immune system on the cognitive performance and abnormal
behaviors seen in mental disorders such as schizophrenia have never been documented …

The immunological response to traumatic brain injury

EJ Needham, A Helmy, ER Zanier, JL Jones… - Journal of …, 2019 - Elsevier
Traumatic brain injury (TBI) is the leading cause of death and disability in young adults in the
developed world. The accuracy of early outcome-prediction remains poor even when all …

Degenerative and regenerative mechanisms governing spinal cord injury

C Profyris, SS Cheema, DW Zang, MF Azari… - Neurobiology of …, 2004 - Elsevier
Spinal cord injury (SCI) is a major cause of disability, and at present, there is no universally
accepted treatment. The functional decline following SCI is contributed to both direct …

Neuroinflammation, oxidative stress, and the pathogenesis of Parkinson's disease

RL Mosley, EJ Benner, I Kadiu, M Thomas… - Clinical neuroscience …, 2006 - Elsevier
Neuroinflammatory processes play a significant role in the pathogenesis of Parkinson's
disease (PD). Epidemiologic, animal, human, and therapeutic studies all support the …