Co-culture approaches for cultivated meat production

S David, A Tsukerman, D Safina… - Nature Reviews …, 2023 - nature.com
The need and demand for sustainable, nutritious and animal-welfare-conscious meat
substitutes has spurred research into cultivated meat production. Meat mainly contains …

[HTML][HTML] Efficient differentiation of bone marrow mesenchymal stem cells into endothelial cells in vitro

C Wang, Y Li, M Yang, Y Zou, H Liu, Z Liang… - European Journal of …, 2018 - Elsevier
Objective Endothelial cells (ECs) play an important role in neovascularisation, but are too
limited in number for adequate therapeutic applications. Mesenchymal stem cells (MSCs) …

[HTML][HTML] Optimization of co-culture conditions for a human vascularized adipose tissue model

F Yang, RN Cohen, EM Brey - Bioengineering, 2020 - mdpi.com
In vitro adipose tissue models can be used to provide insight into fundamental aspects of
adipose physiology. These systems may serve as replacements for animal models, which …

Cell‐derived and enzyme‐based decellularized extracellular matrix exhibit compositional and structural differences that are relevant for its use as a biomaterial

S Nellinger, I Mrsic, S Keller, S Heine… - Biotechnology and …, 2022 - Wiley Online Library
Due to its availability and minimal invasive harvesting human adipose tissue‐derived
extracellular matrix (dECM) is often used as a biomaterial in various tissue engineering and …

[HTML][HTML] Construction of vascularized tissue-engineered breast with dual angiogenic and adipogenic micro-tissues

R Ni, C Luo, H Ci, D Sun, R An, Z Wang, J Yang, Y Li… - Materials Today Bio, 2023 - Elsevier
Hydrogel-based micro-tissue engineering technique, a bottom-up approach, is promising in
constructing soft tissue of large size with homogeneous spatial distribution and superior …

[HTML][HTML] PFKFB3-mediated glycometabolism reprogramming modulates endothelial differentiation and angiogenic capacity of placenta-derived mesenchymal stem …

Y Zhang, Y Zhong, W Liu, F Zheng, Y Zhao… - Stem cell research & …, 2022 - Springer
Abstract Background Mesenchymal stem cells (MSCs) have a great potential ability for
endothelial differentiation, contributing to an effective means of therapeutic angiogenesis …

Comparing the use of differentiated adipose-derived stem cells and mature adipocytes to model adipose tissue in vitro

AC Volz, B Omengo, S Gehrke, PJ Kluger - Differentiation, 2019 - Elsevier
In vitro models of human adipose tissue may serve as beneficial alternatives to animal
models to study basic biological processes, identify new drug targets, and as soft tissue …

[HTML][HTML] Organ-on-a-disc: A platform technology for the centrifugal generation and culture of microphysiological 3D cell constructs amenable for automation and …

S Schneider, F Erdemann, O Schneider… - APL …, 2020 - pubs.aip.org
ABSTRACT Organ-on-a-chip (OoC) systems have evolved to a promising alternative to
animal testing and traditional cell assays in drug development and enable personalization …

Interactions of methacryloylated gelatin and heparin modulate physico-chemical properties of hydrogels and release of vascular endothelial growth factor

C Claaßen, A Southan, J Grübel, GEM Tovar… - Biomedical …, 2018 - iopscience.iop.org
Gelatin hydrogels are used as tissue engineering scaffolds and systems for controlled
release due to their inherent biodegradability and biocompatibility. In this study gelatin …

Adipose stem cell‐derived extracellular matrix represents a promising biomaterial by inducing spontaneous formation of prevascular‐like structures by mvECs

S Nellinger, I Schmidt, S Heine… - Biotechnology and …, 2020 - Wiley Online Library
Tissue constructs of physiologically relevant scale require a vascular system to maintain cell
viability. However, in vitro vascularization of engineered tissues is still a major challenge …