Regulatory mechanisms of immune checkpoints PD-L1 and CTLA-4 in cancer
The cytotoxic T-lymphocyte–associated antigen 4 (CTLA-4)/B7 and programmed death 1
(PD-1)/programmed cell death-ligand 1 (PD-L1) are two most representative immune …
(PD-1)/programmed cell death-ligand 1 (PD-L1) are two most representative immune …
Understanding MAPK signaling pathways in apoptosis
J Yue, JM López - International journal of molecular sciences, 2020 - mdpi.com
MAPK (mitogen-activated protein kinase) signaling pathways regulate a variety of biological
processes through multiple cellular mechanisms. In most of these processes, such as …
processes through multiple cellular mechanisms. In most of these processes, such as …
[HTML][HTML] Multi-organ proteomic landscape of COVID-19 autopsies
X Nie, L Qian, R Sun, B Huang, X Dong, Q Xiao… - Cell, 2021 - cell.com
The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear,
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …
preventing effective therapeutics development. Here, we report a proteomic analysis of 144 …
Molecular mechanisms of dermal aging and antiaging approaches
JW Shin, SH Kwon, JY Choi, JI Na, CH Huh… - International journal of …, 2019 - mdpi.com
The dermis is primarily composed of the extracellular matrix (ECM) and fibroblasts. During
the aging process, the dermis undergoes significant changes. Collagen, which is a major …
the aging process, the dermis undergoes significant changes. Collagen, which is a major …
[HTML][HTML] Human prefrontal cortex gene regulatory dynamics from gestation to adulthood at single-cell resolution
Human brain development is underpinned by cellular and molecular reconfigurations
continuing into the third decade of life. To reveal cell dynamics orchestrating neural …
continuing into the third decade of life. To reveal cell dynamics orchestrating neural …
Regulation and function of the PD-L1 checkpoint
Expression of programmed death-ligand 1 (PD-L1) is frequently observed in human
cancers. Binding of PD-L1 to its receptor PD-1 on activated T cells inhibits anti-tumor …
cancers. Binding of PD-L1 to its receptor PD-1 on activated T cells inhibits anti-tumor …
SARS-CoV-2 spike protein promotes IL-6 trans-signaling by activation of angiotensin II receptor signaling in epithelial cells
Cytokine storm is suggested as one of the major pathological characteristics of SARS-CoV-2
infection, although the mechanism for initiation of a hyper-inflammatory response, and multi …
infection, although the mechanism for initiation of a hyper-inflammatory response, and multi …
NRF2 and the Hallmarks of Cancer
The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …
Though recognized originally as a target of chemopreventive compounds that help prevent …
A human circulating immune cell landscape in aging and COVID-19
Y Zheng, X Liu, W Le, L Xie, H Li, W Wen, S Wang… - Protein & …, 2020 - academic.oup.com
Age-associated changes in immune cells have been linked to an increased risk for infection.
However, a global and detailed characterization of the changes that human circulating …
However, a global and detailed characterization of the changes that human circulating …
Dynamic mapping of proteome trafficking within and between living cells by TransitID
W Qin, JS Cheah, C Xu, J Messing, BD Freibaum… - Cell, 2023 - cell.com
The ability to map trafficking for thousands of endogenous proteins at once in living cells
would reveal biology currently invisible to both microscopy and mass spectrometry. Here, we …
would reveal biology currently invisible to both microscopy and mass spectrometry. Here, we …