Synthetic biology of plant natural products: From pathway elucidation to engineered biosynthesis in plant cells

X Zhu, X Liu, T Liu, Y Wang, N Ahmed, Z Li… - Plant Communications, 2021 - cell.com
Plant natural products (PNPs) are the main sources of drugs, food additives, and new
biofuels and have become a hotspot in synthetic biology. In the past two decades, the …

Subcellular compartmentalization in the biosynthesis and engineering of plant natural produces

L Yao, X Wu, X Jiang, M Shan, Z Zhang, Y Li… - Biotechnology …, 2023 - Elsevier
Plant natural products (PNPs) are specialized metabolites with diverse bioactivities. They
are extensively used in the pharmaceutical, cosmeceutical and food industries. PNPs are …

A new synthetic biology approach allows transfer of an entire metabolic pathway from a medicinal plant to a biomass crop

P Fuentes, F Zhou, A Erban, D Karcher, J Kopka… - elife, 2016 - elifesciences.org
Artemisinin-based therapies are the only effective treatment for malaria, the most
devastating disease in human history. To meet the growing demand for artemisinin and …

[HTML][HTML] Future trends in synthetic biology—a report

M El Karoui, M Hoyos-Flight, L Fletcher - Frontiers in bioengineering …, 2019 - frontiersin.org
Leading researchers working on synthetic biology technologies and their applications
gathered at the University of Edinburgh in May 2018 to discuss the latest challenges and …

Plant defense chemicals against insect pests

JP Yactayo-Chang, HV Tang, J Mendoza… - Agronomy, 2020 - mdpi.com
Insect pests cause significant global agricultural damage and lead to major financial and
environmental costs. Crops contain intrinsic defenses to protect themselves from such pests …

Development and applications of transplastomic plants; a way towards eco-friendly agriculture

MJ Hossain, A Bakhsh - Environment, climate, plant and vegetation …, 2020 - Springer
With distribution of genetic materials and advance molecular characteristics, the chloroplast
is prokaryotic compartments within the eukaryotic plants that have turned into a crucial …

Phototrophic production of heterologous diterpenoids and a hydroxy-functionalized derivative from Chlamydomonas reinhardtii

KJ Lauersen, J Wichmann, T Baier, SC Kampranis… - Metabolic …, 2018 - Elsevier
Photosynthetic microalgae harbor enormous potential as light-driven green-cell factories for
sustainable bio-production of a range of natural and heterologous products such as …

Engineering metabolism in Nicotiana species: a promising future

FJ Molina-Hidalgo, M Vazquez-Vilar, L D'Andrea… - Trends in …, 2021 - cell.com
Molecular farming intends to use crop plants as biofactories for high value-added
compounds following application of a wide range of biotechnological tools. In particular, the …

Plastid transformation and its application in metabolic engineering

P Fuentes, T Armarego-Marriott, R Bock - Current opinion in biotechnology, 2018 - Elsevier
Highlights•A new selectable marker and an improved inducible expression system for
plastids.•Plastid engineering provides access to a large repertoire of metabolic pathways.• …

Reconstitution of monoterpene indole alkaloid biosynthesis in genome engineered Nicotiana benthamiana

QM Dudley, S Jo, DAS Guerrero, M Chhetry… - Communications …, 2022 - nature.com
Monoterpene indole alkaloids (MIAs) are a diverse class of plant natural products that
include a number of medicinally important compounds. We set out to reconstitute the …