Optimized CRISPR/cas9 systems and methods for gene editing in stem cells

JL Gori - US Patent 11,390,884, 2022 - Google Patents
QFJCIRLUMZQUOT-HPLJOQBZSA-N Sirolimus Chemical compound C1C [C@@ H](O)[C@
H](OC) C [C@@ H] 1C [C@@ H](C)[C@ H] 1OC (= O)[C@@ H] 2CCCCN2C (= O) C …

Large scale acoustic separation device

B Lipkens, WM Presz Jr, J King, J Barnes… - US Patent …, 2020 - Google Patents
Devices for separating a host fluid from a second fluid or particulate are disclosed. The
devices include an acoustic chamber, a fluid outlet at a top end of the acoustic chamber, a …

Acoustophoretic separation technology using multi-dimensional standing waves

B Lipkens, J Dionne, WM Presz Jr… - US Patent …, 2020 - Google Patents
A system having improved trapping force for acoustophoresis is described where the
trapping force is improved by manipulation of the frequency of the ultrasonic transducer. The …

Acoustic perfusion devices

B Lipkens, R Gilmanshin, L Masi… - US Patent …, 2021 - Google Patents
2017-08-30 Assigned to Flodesign Sonics, Inc. reassignment Flodesign Sonics, Inc.
ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors …

System for generating high concentration factors for low cell density suspensions

B Lipkens, J Dionne, G Ghoshal - US Patent 10,308,928, 2019 - Google Patents
Acoustophoretic devices and methods for concentrating targeted biological cells in a
reduced volume using multi-dimensional acoustic standing waves are disclosed. The …

Acoustic perfusion devices

B Lipkens, E Miller, B Ross-Johnsrud… - US Patent …, 2020 - Google Patents
Acoustic perfusion devices for separating biological cells from other material in a fluid
mixture are disclosed. The devices include an inlet port, an outlet port, and a collection port …

Driver and control for variable impedence load

B Lipkens, R Musiak, D Mealey, J Artis… - US Patent …, 2021 - Google Patents
US10967298B2 - Driver and control for variable impedence load - Google Patents
US10967298B2 - Driver and control for variable impedence load - Google Patents Driver and …

CRISPR/Cas-related methods and compositions for improving transplantation

JL Gori, T Wang, H Jayaram, P Odonnell - US Patent 11,911,415, 2024 - Google Patents
US11911415B2 - CRISPR/Cas-related methods and compositions for improving transplantation
- Google Patents US11911415B2 - CRISPR/Cas-related methods and compositions for …

Therapeutic cell washing, concentration, and separation utilizing acoustophoresis

B Lipkens, J Dionne, WM Presz Jr, B Dutra - US Patent 11,085,035, 2021 - Google Patents
Multi-stage acoustophoretic devices for continuously separating a second fluid or a
particulate from a host fluid are disclosed. Methods of operating the multi-stage …

Transducer and reflector configurations for an acoustophoretic device

B Lipkens, WM Presz Jr, K Chitale, B McCarthy… - US Patent …, 2019 - Google Patents
Separation of particles or droplets from a host fluid may be achieved using a transducer
and/or reflector that is a thin, non-planar structure. The thin non-planar structure improves …