Time to incorporate preemptive NUDT15 testing before starting thiopurines in inflammatory bowel disease in Asia and beyond: a review
Introduction Thiopurine toxicity is related to genetic polymorphism. Thiopurine
methyltransferase (TPMT) variants do not explain thiopurine toxicity in more than half of …
methyltransferase (TPMT) variants do not explain thiopurine toxicity in more than half of …
Uphill battle: Innovation of thiopurine therapy in global inflammatory bowel disease care
AB Bayoumy, CJJ Mulder, AR Ansari… - Indian Journal of …, 2024 - Springer
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal
tract that encompasses two major conditions: Crohn's disease (CD) and ulcerative colitis …
tract that encompasses two major conditions: Crohn's disease (CD) and ulcerative colitis …
TPMT and NUDT15 polymorphisms in thiopurine induced leucopenia in inflammatory bowel disease: a prospective study from India
Background Polymorphisms in thiopurine methyltransferase (TPMT) and Nudix hydrolase-
15 (NUDT15) have been implicated as the predominant cause of thiopurine induced …
15 (NUDT15) have been implicated as the predominant cause of thiopurine induced …
Innovating thiopurine therapeutic drug monitoring: a systematic review and meta-analysis on DNA-thioguanine nucleotides (DNA-TG) as an inclusive biomarker in …
AB Bayoumy, AR Ansari, CJJ Mulder… - Clinical …, 2024 - Springer
Abstract Background and Objective Thioguanine (TG), azathioprine (AZA), and
mercaptopurine (MP) are thiopurine prodrugs commonly used to treat diseases, such as …
mercaptopurine (MP) are thiopurine prodrugs commonly used to treat diseases, such as …
Safety and efficacy of personalized versus standard initial dosing of thiopurines: Systematic review and meta-analysis of randomized trials
A Jena, CL Birda, A Choudhury… - Expert Opinion on Drug …, 2023 - Taylor & Francis
Background Pretherapy assessment of specific genetic polymorphism (TPMT, NUDT15,
FTO, RUNX1, etc) or enzyme levels (for TPMT) may help personalize the dose of thiopurines …
FTO, RUNX1, etc) or enzyme levels (for TPMT) may help personalize the dose of thiopurines …
Pharmacogenomic assessment of genes implicated in thiopurine metabolism and toxicity in a UK cohort of pediatric patients with inflammatory bowel disease
T Coelho, G Cheng, S Lewis, JJ Ashton… - Inflammatory Bowel …, 2024 - academic.oup.com
Background Thiopurine drugs are effective treatment options in inflammatory bowel disease
and other conditions but discontinued in some patients due to toxicity. Methods We …
and other conditions but discontinued in some patients due to toxicity. Methods We …
Minimal risk of lymphoma and non‐melanoma skin cancer despite long‐term use of thiopurines in patients with inflammatory bowel disease: a longitudinal cohort …
MK Ranjan, B Kante, SK Vuyyuru… - Journal of …, 2022 - Wiley Online Library
Abstract Background and Aim Thiopurines are widely used to maintain remission in both
ulcerative colitis (UC) and Crohn's disease (CD). Reported effectiveness and tolerability …
ulcerative colitis (UC) and Crohn's disease (CD). Reported effectiveness and tolerability …
Effectiveness and safety of thioguanine as a maintenance therapy of inflammatory bowel disease: Systematic review, meta-analysis and meta-regression
A Jena, PB Neelam, H Telaprolu, UK Mangipudi… - Clinics and Research in …, 2023 - Elsevier
Introduction Thiopurines are an important therapy for the maintenance of remission in
inflammatory bowel disease (IBD). However, the use of thioguanine has been limited by …
inflammatory bowel disease (IBD). However, the use of thioguanine has been limited by …
Population-Specific Distribution of TPMT Deficiency Variants and Ancestry Proportions in Ecuadorian Ethnic Groups: Towards Personalized Medicine
J Gallardo-Cóndor, P Naranjo… - … and Clinical Risk …, 2023 - Taylor & Francis
Purpose Thiopurine S-methyltransferase (TPMT) is an enzyme that metabolizes purine
analogs, agents used in the treatment of acute lymphoblastic leukemia. Improper drug …
analogs, agents used in the treatment of acute lymphoblastic leukemia. Improper drug …
[HTML][HTML] ITPA polymorphisms do not predict additional risk beyond TPMT and NUDT15 for thiopurine-induced cytopenia in inflammatory bowel disease
Introduction and aim Thiopurine-related leukopenia is associated with polymorphisms in the
thiopurine methyltransferase (TPMT) and nucleoside diphosphate-linked moiety X type motif …
thiopurine methyltransferase (TPMT) and nucleoside diphosphate-linked moiety X type motif …